Pentraxin-3 in Chronic Renal Failure

Completed

• Conditions: Chronic Kidney Disease; Inflammation

• Registration Number: NCT01397773
• Lead Sponsor: Haseki Training and Research Hospital

Brief Summary

The aim of the study is to measure Pentraxin-3 levels in patients on hemodialysis, peritoneal dialysis and those in the pre-dialysis period; and to compare these groups with the control group; so as to investigate the eligibility of it as a reliable marker of inflammation; relationship with other inflammatory markers and carotis intima media thickness.

Detailed Description

The investigators planned to involve four group of patients: Hemodialysis, peritoneal dialysis, pre-dialysis and the control group; with about 25 patients planned to be involved in each group. The laboratory parameters to be measured are Pentraxin-3, C-reactive protein (CRP), high sensitive CRP, fibrinogen and interleukin-6. Concomitantly, carotis intima media thickness will be measured in the radiology clinic. Statistical analysis will be carried on by Statistical Package for Social Sciences (SPSS) for Windows 13.0. The variables acting on the inflammatory parameters and the correlation between them and carotis intima media thickness will be studied.

Study Timeline

• Study Start: 2010-04
• Primary Completion: 2011-01
• Study Completion: 2011-01
• Status Verified: 2011-07
• Study First Submitted: 2011-07-18
• Study First Submitted QC: 2011-07-19
• Last Update Submitted: 2011-07-19
• Study First Posted: 2011-07-20
• Last Update Posted: 2011-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• To give informed consent
• Hemodialysis or peritoneal dialysis for more than 3 months
• Creatinin clearance less than 30 ml/min for the pre-dialysis group

Exclusion Criteria

• Not to give informed concent
• Active infection within the last 3 months
• Known chronic inflammatory disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pentraxin-3 level	Five months	Pentraxin-3 level will be compared with other inflammatory markers.

Secondary Outcome Measures

Name	Time	Method
Carotis intima media thickness	Five months	Correlation of Pentraxin-3 and carotis intima media thickness

Trial Locations

Locations (1)

Haseki Training and Research Hospital; 🇹🇷 Istanbul, Turkey