CTRI/2024/11/076939尚未招募Unknown
Impact of Oral Probiotic Paste on Antimicrobial Resistance in Patients with Generalized Periodontitis: A Quasi-Experimental Study
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- SELF
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Expression of ermT and vanX genes
研究概览
简要总结
Recently probiotics have emerged as a promising adjunct to scaling and root planing. However, its clinical benefits are still not proven as per existing evidence. Recent in vitro studies have reported antimicrobial resistance genes in commonly used oral probiotic lozenges. However clinical studies have not been carried out in this regard. This study intends to evaluate the impact of probiotic toothpaste on anti-microbial resistance genes of microorganisms in dental plaque.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •Systemically healthy patients with generalized periodontitis belonging to both sexes aged between 30-60 years will be selected.
排除标准
- •Pregnant and lactating females • Immunocompromised patient • Periodontal or orthodontic treatment at least 6 months before the start of the study • Use of antibiotics, corticosteroids, and antiâ€inflammatory drugs within 3 months before sampling.
结局指标
主要结局
Expression of ermT and vanX genes
时间窗: 1 MONTH
次要结局
- plaque index, bleeding on probing(1 month)
研究者
AMRUTHA THANKAM BABUJI
PMS College of Dental Science and Research
研究点 (1)
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