CTRI/2024/11/076939Not yet recruitingUnknown
Impact of Oral Probiotic Paste on Antimicrobial Resistance in Patients with Generalized Periodontitis: A Quasi-Experimental Study
Trial Snapshot
- Phase
- Unknown
- Status
- Not yet recruiting
- Sponsor
- SELF
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Expression of ermT and vanX genes
Study Overview
Brief Summary
Recently probiotics have emerged as a promising adjunct to scaling and root planing. However, its clinical benefits are still not proven as per existing evidence. Recent in vitro studies have reported antimicrobial resistance genes in commonly used oral probiotic lozenges. However clinical studies have not been carried out in this regard. This study intends to evaluate the impact of probiotic toothpaste on anti-microbial resistance genes of microorganisms in dental plaque.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 30.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Systemically healthy patients with generalized periodontitis belonging to both sexes aged between 30-60 years will be selected.
Exclusion Criteria
- •Pregnant and lactating females • Immunocompromised patient • Periodontal or orthodontic treatment at least 6 months before the start of the study • Use of antibiotics, corticosteroids, and antiâ€inflammatory drugs within 3 months before sampling.
Outcomes
Primary Outcomes
Expression of ermT and vanX genes
Time Frame: 1 MONTH
Secondary Outcomes
- plaque index, bleeding on probing(1 month)
Investigators
AMRUTHA THANKAM BABUJI
PMS College of Dental Science and Research
Study Sites (1)
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