跳至主要内容
临床试验/CTRI/2024/11/076939
CTRI/2024/11/076939尚未招募Unknown

Impact of Oral Probiotic Paste on Antimicrobial Resistance in Patients with Generalized Periodontitis: A Quasi-Experimental Study

SELF1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年12月16日最近更新:

试验速览

阶段
Unknown
状态
尚未招募
发起方
SELF
入组人数
30
试验地点
1
主要终点
Expression of ermT and vanX genes

研究概览

简要总结

Recently probiotics have emerged as a promising adjunct to scaling and root planing. However, its clinical benefits are still not proven as per existing evidence. Recent in vitro studies have reported antimicrobial resistance genes in commonly used oral probiotic lozenges. However clinical studies have not been carried out in this regard. This study intends to evaluate the impact of probiotic toothpaste on anti-microbial resistance genes of microorganisms in dental plaque.

研究设计

研究类型
Observational

入排标准

年龄范围
30.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Systemically healthy patients with generalized periodontitis belonging to both sexes aged between 30-60 years will be selected.

排除标准

  • Pregnant and lactating females • Immunocompromised patient • Periodontal or orthodontic treatment at least 6 months before the start of the study • Use of antibiotics, corticosteroids, and anti‐inflammatory drugs within 3 months before sampling.

结局指标

主要结局

Expression of ermT and vanX genes

时间窗: 1 MONTH

次要结局

  • plaque index, bleeding on probing(1 month)

研究者

发起方
SELF
申办方类型
Other []
责任方
Principal Investigator
主要研究者

AMRUTHA THANKAM BABUJI

PMS College of Dental Science and Research

研究点 (1)

Loading locations...

相似试验