Impact of Long Term of Benzodiazepine Use on Psychiatric Manifestation

• Conditions: Psychiatric Disorder; Benzodiazepine-Related Disorders

• Registration Number: NCT04792658
• Lead Sponsor: Assiut University

Brief Summary

Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs. Few cases of addiction arise from legitimate use of benzodiazepines. Pharmacologic dependence, a predictable and natural adaptation of a body system long accustomed to the presence of a drug, may occur in patients taking therapeutic doses of benzodiazepines. However, this dependence, which generally manifests itself in withdrawal symptoms upon the abrupt discontinuation of the medication, may be controlled and ended through dose tapering, medication switching, and/or medication augmentation. Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction.

previous study reported that The results of the study are important in that they corroborate the mounting evidence that a range of neuropsychological functions are impaired as a result of long-term benzodiazepine use, and that these are likely to persist even following withdrawal. The findings highlight the residual neurocognitive compromise associated with long-term benzodiazepine therapy as well as the important clinical implications of these results.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-03
• Study First Submitted: 2021-03-08
• Study First Submitted QC: 2021-03-08
• Last Update Submitted: 2021-03-08
• Study Start: 2021-03-10
• Study First Posted: 2021-03-11
• Last Update Posted: 2021-03-11
• Primary Completion: 2022-06-20
• Study Completion: 2023-09-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age from 18 years to 50 years
• No history of neurological or medical illness

Exclusion Criteria

• intelligence score more than 80

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
measure of risk factor of DSM 5 psychiatric disorders associated with long term of benzodiazepine use	through study completion, an average of 1 year
measure the prevalence of DSM 5 psychiatric disorders associated with long term of benzodiazepine use	through study completion, an average of 1 year