The Screening and Analysis of Plasma Biomarkers in Irreversible Pulmonary Arterial Hypertension Associated With Congenital Heart Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension,Pulmonary
- Sponsor
- Shanghai Jiao Tong University School of Medicine
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- the number of Circulation endothelial cells and the detective count of microRNAs
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to analyse the sensitivity and specificity of circulating endothelial cells to predict irreversible pulmonary arterial hypertension associated with congenital heart disease.
Detailed Description
predict to recruit 100 patients with pulmonary arterial hypertension (PAH)associated with CHD，under the commitment of the children's parents，take 3-4ml central venous blood before the corrective surgery，then calculate the number of the circulating endothelial cells by flow cytometer AND detect the expression of micro RNAs to screen out the biomarker，through the 6 months follow-up, separated the reversible and irreversible PAH,then to carry on the statistics.
Investigators
Xu Zhuoming
Vice Chief, Department of thoracic and cardiovascular surgery
Shanghai Jiao Tong University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Only those patients with systolic PAP (sPAP) \>65mmHg before surgery were included.
Exclusion Criteria
- •Patients with trisomy 21 (Down syndrome) were not included
Outcomes
Primary Outcomes
the number of Circulation endothelial cells and the detective count of microRNAs
Time Frame: 6 months after corrective surgery
the number of Circulation endothelial cells and the detective count of microRNAs in the biomarkers in both groups differd significantly.