Effects of Resistant Starch in a Baked Snack Bar on a Post-prandial Glycemic and Insulinemic Response

Not Applicable

• Conditions: Hyperglycemia, Diabetes, and Obesity
• Interventions: Dietary Supplement: Resistant starch

• Registration Number: NCT02187913
• Lead Sponsor: Purdue University

Brief Summary

* About two-thirds of adults in the United States are overweight or obese which can cause adverse health consequences for those individuals. Post-prandial hyperglycemia is one of these possible consequences and is associated with a higher risk for Type 2 Diabetes. Controlling hyperglycemia is important in the prevention of the onset of diabetes and obesity. Resistant starch is a dietary carbohydrate which is not completely digested in the gut and produces energy for the body to use. The investigators are interested in assessing the effects of resistant starch on postprandial blood glucose and insulin concentrations.

* Aim: To assess the effects of a resistant starch on post-prandial blood glucose and insulin concentrations.

* Hypothesis: A baked snack bar with a resistant starch will blunt and sustain the post-prandial rise in blood glucose and insulin concentrations compared to a baked snack bar with maltodextrin (an easily digested carbohydrate).

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-07
• Study Start: 2014-07
• Study First Submitted: 2014-07-09
• Study First Submitted QC: 2014-07-10
• Last Update Submitted: 2014-07-10
• Study First Posted: 2014-07-11
• Last Update Posted: 2014-07-11
• Primary Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Thirty healthy men and women (aged 18-29y) will be recruited from the greater Lafayette, IN region with the expectation that ≥20 subjects will complete the study. Subjects must weigh >110 pounds, with a BMI between 20.0 and 29.9.

Exclusion Criteria

• Weight change > 3kg in the past 3 months
• Exercising vigorously over the past 3 months as well as no exercise 3 days prior to testing day
• Intestinal disorders including lipid mal-absorption or lactose intolerance
• Abnormal liver or kidney function tests; fasting blood glucose >100mg/dL
• Smoking
• Drinking more than 2 alcoholic drinks per day
• Taking lipid-lowering medications or dietary supplements affecting plasma cholesterol concentration.
• Subjects must not be pregnant or lactating.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Resistant starch	Resistant starch	The test snack bar consumed has the resistant starch
Control	Resistant starch	The control bar uses maltodextrin rather than the resistant starch.

Primary Outcome Measures

Name	Time	Method
resistant starch effects	2 weeks	effects of resistant starch consumption of area under the curve of blood serum glucose, insulin, and hydrogen breath testing

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States