Randomised trial to compare the clinical value of cyclosporin C12 and C2 monitoring after lung transplantatio

Not Applicable

Completed

• Conditions: ung transplant recipients; Surgery; Transplanted organ and tissue status

• Registration Number: ISRCTN17970029
• Lead Sponsor: Papworth Hospital NHS Trust (UK)

Brief Summary

1. 2004 results presented at 24th International Society of Heart and Lung Transplantation https://www.jhltonline.org/article/S1053-2498(03)00838-6/fulltext 2. 2005 results presented at 25th International Society of Heart and Lung Transplantation https://www.jhltonline.org/article/S1053-2498(04)00744-2/fulltext

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-07-08
• Study Completion: 2006-04-01
• Last Update Posted: 30 July 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

90 patients lung transplant:
1. Adult single or double lung and heart + lung transplant recipients (18 years and older)
2. Patients receiving Neoral as primary immunosuppression

Exclusion Criteria

1. Patients not giving voluntary, written informed consent to participate
2. Re-transplantation
3. Simultaneous kidney, pancreas, liver or bowel transplantation
3. Urine output <50 ml/hour and/or serum creatinine =170 mmol/l at the most recent investigation prior to transplantation
4. Renal replacement therapy or any form of renal support such as continuous veno-venous haemofiltration (CVVH) or dialysis before transplantation or within the first post-operative week
5. Patients receiving tacrolimus or sirolimus as primary immuno-suppression in place of Neoral

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal function at 3 months post transplant

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration