Cefazolin Dosing in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass

University Hospital, Ghent0 个研究点目标入组 56 人开始时间: 2012年12月最近更新: 2023年5月18日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University Hospital, Ghent
入组人数: 56
主要终点: Assessment of the time during which the unbound cefazolin concentration is above the MIC of S. aureus (fT>MIC) with the current dosing regimen

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

Pharmacokinetics of cefazolin in children undergoing cardiac surgery.

研究设计

研究类型: Observational
观察模型: Other
时间视角: Prospective

入排标准

年龄范围: 0 Days 至 15 Years（Child）
性别: All
接受健康志愿者: 否

入选标准

•pediatric patients undergoing cardiac surgery with cardiopulmonary bypass
•minimum weight 1.8 kg
•intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

排除标准

•no catheter in place for blood sampling
•absence of parental/patient consent
•known hypersensitivity to cefazolin

结局指标

主要结局

Assessment of the time during which the unbound cefazolin concentration is above the MIC of S. aureus (fT>MIC) with the current dosing regimen

时间窗: 3 years

次要结局

Optimalisation of the cefazolin dosing regimen to aim for a target unbound cefazolin concentration above the MIC of S. aureus during surgery(3 years)

研究者

发起方

University Hospital, Ghent

申办方类型

Other

责任方

Sponsor

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