ACTRN12611000705987
Terminated
未知
A multi-site cluster randomised controlled trial comparing the severity of constipation symptoms experienced by palliative care patients receiving usual care compared to those diagnosed and managed according to the underlying pathophysiology.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Constipation
- Sponsor
- Flinders University
- Enrollment
- 210
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Life\-limiting disease
- •Aged 18 years or older
- •Regular use of laxatives
- •Already receiving one or more laxatives for at least 48 hours, as suggested in the Australian Palliative Care Therapeutic Guidelines
- •Sufficient proficiency in English to provide consent, complete the study questionnaires and telephone interviews
- •Willing and able to undertake diagnostic interventions
- •Able to give fully informed written consent
Exclusion Criteria
- •Short\-term constipation due to problems such hypercalcaemia or vinca alkylating agents occurring within one month of study
- •History of bowel obstruction or at high risk of bowel obstruction (peritoneal disease)
- •History of bowel surgery
- •Local conditions of the peri\-anal area and rectum that would contribute to pain on defecation, require specialist interventions and therefore preclude the necessary investigatons to continue on this study including faecal impaction, anal fissure, haemorrhoids, anal prolapse or rectocele \>2cm in size
- •Thrombocytopenia of \<50,000 platelets per microlitre precluding rectal interventions
- •Allergy to latex
- •Participants who have participated in a clinical study of a new laxative within one month prior to study entry
- •Women who are pregnant. Patients at risk of pregnancy must have appropriate and effective contraceptive in place (or appropriate advice from their doctor regarding appropriate birth control)
- •Any other condition that would interfere with study procedures or assessments in the opinion of the investigators
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Stand Together: supporting children’s social and emotional wellbeing in schoolsISRCTN12300853Bangor University12,580
Terminated
Not Applicable
The FRANK friends study: a multicentre cluster randomised controlled trial evaluating a school-based drug prevention interventioPrevention of illicit drugsNot ApplicableISRCTN72047541Cardiff University6,754
Completed
Not Applicable
Primary care Electronic Referrals: Focus on Efficient Consultation using Telemedicine in DermatologySkin complaintsSkin and Connective Tissue DiseasesISRCTN57478950KSYOS Health Management Research BV (The Netherlands)1,000
Recruiting
Not Applicable
A multicenter, cluster randomized controlled trial to investigate the effectiveness of the treatment guideline for major depressive disorder in JapaMajor depressive disorderJPRN-UMIN000034397Japan Agency for Medical Research and Development204
Completed
Not Applicable
Assessing the effectiveness of the Little Journey app at reducing children’s anxiety before surgeryISRCTN23410641niversity College London304