Transversus Abdominis Plane Block Combined With Rectus Sheath Block Versus Erector Spinae Plane Block for Postoperative Analgesia After Laparoscopic Liver Resection
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The dose of morphine used
研究概览
简要总结
Postoperative pain after laparoscopic hepatectomy is composed of multiple factors, and the peak pain of postoperative pain mainly occurs within the first 24 hours, so it is particularly important to find an appropriate analgesic method. Transversus abdominis plane block (TAPB) and Rectus sheath blocks (RSB) are widely used in abdominal surgery, but too deep a needle tip during RSB may puncture abdominal organs. TAPB and RSB can only provide somatic analgesia, but lack visceral analgesia. Recently, Erector spinae plane block (ESPB) has been used in some studies for analgesia after abdominal surgery. The purpose of this study is to compare the analgesic effect and postoperative recovery effect of erector spinae plane block and transverse abdominis plane block combined with rectus sheath block in patients undergoing laparoscopic hepatectomy. Therefore, this study has important clinical implications.
详细描述
In a double-blind randomized controlled study, researchers randomized 60 patients undergoing laparoscopic hepatectomy to TAPB combined with RSB or ESPB, with both groups receiving additional standardized treatment, including multimodal analgesia. The main outcome was the consumption of morphine within 24 hours after surgery. Secondary outcomes included the number of rescue analgesia at 1h, 2h, 4h, 8h and 24 hours after surgery, VAS scores in resting and coughing at 1h, 2h, 4h, 8h and 24h after surgery, CVP values at 5, 10, 15 and 30min after nerve block, QoR-15 patient questionnaire scores before and 24h after surgery, and postoperative liver function (the percentage increase of AST and ALT compare with preoperative), postoperative complications and discharge time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA grades I-II;
- •Age 18~70 years old;
- •BMI 19～28kg/m2;
- •Patients undergoing elective laparoscopic partial liver resection;
排除标准
- •The nerve block cannot be performed, such as skin infection at the puncture site;
- •Daily using the opioid analgesics or have a history of opioid abuse;
- •Allergy or a history of drug allergy to any of the drugs used in the study;
- •Patients have cognitive impairment, mental or neurological diseases, motor or sensory deficits;
- •Coagulation disorders;
- •Severe lung, heart, liver, or kidney dysfunction;
- •Participating in other clinical trials within 3 months before being included in this study;
结局指标
主要结局
The dose of morphine used
时间窗: 24 hours after surgery
dosage of analgesic pump
次要结局
- The number of rescue analgesia(1hour, 2hours, 4hours, 8hours and 24hours after surgery)
- Quantitative assessment of liver function(before and 1days, 3days after surgery)
- Recovery time nodes(follow up patients for an average of half a month)
- QoR-15 scores(before and 24h after surgery)
- The value of central venous pressure(5min, 10min, 15min and 30min after nerve block)
- Postoperative Complications(2hours, 4hours, 8hours and 24hours after surgery)
- The dose of morphine used(1hour, 2hours, 4hours and 8hours after surgery)
- Visual analogue scale scores in resting and coughing state(1hour, 2hours, 4hours, 8hours and 24hours after surgery)
研究者
Zhangyi
Professor
Tongji Hospital