NCT02325882已完成不适用
The Postoperative Analgesic Effect of Combination With Dexmedetomidine in Fentanyl-based Intravenous Patient Controlled Analgesia Compared With Conventional Thoracic Epidural and Intravenous Patient Controlled Analgesia After Radical Open Gastrectomy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 171
- 试验地点
- 1
- 主要终点
- Postoperative pain
研究概览
简要总结
The aim of this study to test hypothesis that addition of dexmedetomidine to fentanyl based intravenous patient controlled analgesia (PCA) improves postoperative pain compared with conventional thoracic epidural and intravenous patient controlled analgesia after radical open gastrectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA class I-II
- •obtaining written informed consent from the parents
- •aged 20-65 years who were undergoing radical open gastrectomy
排除标准
- •abdominal surgery previously
- •patient who refuse the patient controlled analgesia
- •unstable angina or congestive heart failure
- •uncontrolled hypertension (diastolic bp>110mmHg)
- •coagulopathy
- •hepatic failure
- •renal failure
- •bradycardia on EKG (under 50 bpm)
- •Ventricular conduction abnormality
- •drug hyperactivity
- •neurological or psychiatric illnesses
- •mental retardation
- •patients who can't read the consent form due to illiterate or foreigner 14.infection
- •obesity (BMI > 30kg/m2)
研究组 & 干预措施
Conventional fentanyl-based intravenous PCA
Active Comparator
干预措施: Fentanyl 2 (Drug)
Conventional fentanyl-based epidural PCA
Active Comparator
干预措施: Fentanyl 1 (Drug)
dexmedetomidine to fentanyl-based intravenous PCA
Experimental
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Postoperative pain
时间窗: 48 hours after operation
Postoperative pain measure using verbal numerical rating scales (VNRS) for 48 hrs
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled TrialPONVNCT01840254Yonsei University108
已完成
4 期
Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing TonsillectomyTonsillitisNCT00654511Children's National Research Institute101
已完成
1 期
A Comparative Study of Intrathecal Dexmedetomidine and Fentanyl As Additives to Bupivacaine in Pott's FracturePost Operative PainNCT06502262Ain Shams University60
已完成
不适用
Influence of Addition of Dexmeditomidine or Fentanyl to Bupivacaine Lumbar Spinal Subarachnoid Anesthesia for Inguinal Hernioplastysuarachnoid, anesthesia, inguinal, hernioplastyAnaesthesiaPACTR201710002669205zagazig university hospitals70
撤回
4 期
Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic RequirementSedationAnalgesiaNCT00852046Avera McKennan Hospital & University Health Center