Psoriasis and compression therapy
- Conditions
- L40R60PsoriasisOedema, not elsewhere classified
- Registration Number
- DRKS00016626
- Lead Sponsor
- niversitätsklinikum Essen
- Brief Summary
Background: Psoriatic plaques at the distal lower extremities are notoriously treatment resistant. Medical compression therapy could potentially be a useful supplementary therapeutic measure at this site. However, there is concern that the Koebner phenomenon may cause a worsening of the skin condition. Therefore, the purpose of this study was to investigate the effects of compression therapy on psoriatic plaques in the presence of coexisting edema of the lower legs. Patients and methods: Compression therapy was performed in addition to standard of care on one lower leg for 4 weeks (half-side test) in patients with psoriatic plaques and edema on both lower legs. The primary endpoint of the study was clinical response of the psoriatic plaques on the lower legs measured with the lesion severity score (LSS) and the locally affected body surface area in a side-by-side comparison at week 4 compared with baseline. Secondary endpoints were related to patient-reported outcomes. Results: Data from 30 patients were included in the analysis. In the descriptive analysis, the mean LSS results and the subjective pain reported by the patients showed a slightly greater improvement on the compressed lower leg compared with the non-compressed lower leg. None of the patients showed evidence of the Koebner phenomenon induced by compression therapy. Conclusion: This is the first clinical study that systematically investigated the impact of compression therapy on psoriatic plaques. During the study period of 4 weeks, there was no significant improvement in psoriatic plaques; however, there was also no evidence of worsening of the skin condition. Thus, anti-edematous compression therapy can be performed in psoriasis patients without causing complications if basic contraindications are considered.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 35
Age = 18
- Psoriasis vulgaris for at least 6 months
- edema on both lower legs
- Psoriatic plaques on both lower legs
- Patient must be able to put compression stockings on and off by her- or himself.
- Inadequate ability to communicate in the German language or lack of comprehension of the German language or dementia or (functional) illiteracy
- Lack of or unwillingness to sign the informed consent form
- Decompensated heart failure
- Advanced polyneuropathy
- Pregnancy and breast feeding period
- Critical ischemia, KADI (ankle-brachial pressure index) <0.5 or absolute blood pressure <60 mmHg
- Known CVI or other illnesses for which compression therapy is already being used
- Floride wound on the lower extremities
- Obesity with BMI> 40
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method