Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency

Completed

• Conditions: Adrenal Insufficiency

• Registration Number: NCT01184209
• Lead Sponsor: University of Wuerzburg

Brief Summary

Prospective study to evaluate incidence, causes and potential risk factors for adrenal crisis in patients with chronic adrenal insufficiency.

Detailed Description

This is a prospective study following patients with chronic adrenal insufficiency by contacting them every 6 months via questionnaires and telephone. QUestionnaires assess incidence and causes of adrenal crisis, frequency of hospitalization.

Study Timeline

• Study Start: 2007-02
• Study First Submitted: 2010-08-17
• Study First Submitted QC: 2010-08-17
• Study First Posted: 2010-08-18
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-03
• Last Update Posted: 2014-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 444

Inclusion Criteria

• chronic primary or secondary adrenal insufficiency requiring glucocorticoid substitution therapy

Exclusion Criteria

• adrenocortical carcinoma
• long term glucocorticoid treatment above 7.5 mg prednisone equivalent dose for other reasons than adrenal insufficiency
• age < 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of adrenal crisis	during study period

Secondary Outcome Measures

Name	Time	Method
mortality	during study period

Trial Locations

Locations (2)

University of Berlin; 🇩🇪 Berlin, Germany

University of Wuerzburg; 🇩🇪 Wuerzburg, Germany