Nutritional Supplement for Patients With Severe Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Severe Infection
- Sponsor
- University of British Columbia
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Plasma HDL
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This is a randomized trial testing a supplement that has been approved by Health Canada to support healthy cholesterol levels (i.e. high density lipoprotein (HDL) cholesterol). This trial is proposing to use this approved supplement to determine whether it is able to raise HDL cholesterol in patients treated in the intensive care unit (ICU) with severe infection who have detrimentally low levels of HDL cholesterol. Patients who present to the ICU with severe infection will be approached for consent. If they choose to participate, patients will be given usual care or a 150mL daily nutritional supplement containing lauric acid (15 ml) and Berberine (1000 mg) daily for 14 days. Participants will be followed during their stay in the ICU and will receive follow up phone calls at Day 28 and 90.
Investigators
john boyd
Associate Professor
University of British Columbia
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of Sepsis
- •plasma high density lipoprotein levels less than 1 mM
- •receiving enteral nutrition
Exclusion Criteria
- •known pregnancy/intending to get pregnant within 28 days of enrollment in study
Outcomes
Primary Outcomes
Plasma HDL
Time Frame: 14 days
Maximum Plasma Concentration \[Cmax\] HDL (mmol)
Secondary Outcomes
- WBC(14 days)
- Cytokines(14 days)
- 28-day survival(28 days)