Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- The elastin content in tissue samples in patients with or without pelvic organ prolapse.
研究概览
简要总结
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
详细描述
The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.
The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •surgery for pelvic organ prolapse
- •hysterectomy due to other benign reasons than pelvic organ prolapse
排除标准
- •surgery due to malignancy
结局指标
主要结局
The elastin content in tissue samples in patients with or without pelvic organ prolapse.
时间窗: september 2012
次要结局
- The collagen content in tissue samples in women with or without pelvic organ prolapse.(September 2012)