A Randomized, Parallel Group, Open Label, Active Controlled Clinical Study to Evaluate the Efficacy and Safety of a Unani Pharmacopeial Formulation Marham Hina in the Management of Buthur Labaniyya (Acne Vulgaris).

Buthur Labaniyya(Acne Vulgaris) is the most common skin disease, affect 9.4% of the global population, making it the eighth most prevalent disease worldwide. According to the GBD study, acne vulgaris affects ~85% of young adults’ aged 12–25 years. Acne causes disfigurement which leads to great psychological, emotional and social impact. Anxiety, depression, bullying, lack of confidence, social withdrawal, feelings of insecurity and inferiority even suicidal ideation. In conventional therapy, there are many drugs are available but none of them are free from side effects. Marham hina, is a potent topical treatment from National Formulary of Unani Medicine for Acne Vulgaris.

This Randomized, Active controlled, Parallel Group, Open Label, Clinical study has planned to evaluate the Efficacy and Safety of Marham Hina in the management of acne vulgaris. Participants fulfilling inclusion and exclusion criteria will be receive either test or control drug as per randomization, in test group participants will be receive Marham Hina ointment local application twice  daily at affected sites as per requirement, in control drug participants will be given benzoyl peroxide 2.5% gel topically twice daily at affected sites as per requirement.  Laboratory investigation will be done at baseline and last follow up. Duration of the study is 6 weeks. For  statistical analysis Student t test will be used to find the statistically significant difference in the parameters within the group/ inter the group.  All the result analysis will be done using MS excel 2019.