Efficacy of Irsal-i-Alaq (Leech Therapy) and Zimad (Paste) in Taqashshur-i-Jild (Psoriasis): A Comparative Randomised Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Evaluation for prognosis with averaged PASI
研究概览
简要总结
Psoriasis is achronic, inflammatory, hyperproliferative skin disease, characterized bywell-defined erythematous scaly plaques particularly affecting the extensorsurfaces and scalp. It usually follows a relapsing and remitting course.
Its management isunsatisfactory in conventional science. The drugs commonly employed forsystemic therapy are corticosteroids, Methotrexate, Retinoids and Cyclosporinsetc. Systemic medication carries a potential for more serious side effects thanthe topical therapy. Long term use of topical steroids causes dermal atrophy,tachyphylaxis and rarely adrenal suppression.
Unani Physiciansmentioned a wide range of treatment for Amraz-i-Jild includingTaqashshur-i-Jild and are treating the condition since a long time without muchserious side effects. The claims of Unani physicians should be validated onauthentic modern scientific parameters for worldwide acceptance. Keeping thesefacts in mind, this study is designed to evaluate the efficacy of Irsal-i-Alaq(Leech Therapy) and Zimad (Paste) in Taqashshur-i-Jild (Psoriasis).
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Clinically diagnosed patients of Taqashshur-i-Jild
- •Willingness to participate in the study and follow the instructions.
排除标准
- •Uncontrolled Diabetes mellitus with RBS > 250 mg/dl
- •Hypotensive patient with BP <100/60mmHg
- •Bleeding disorders
- •Anaemia with Hb <10gm%
- •Acute infection and septicaemia
- •Immuno-compromised patients
- •Pregnant and lactating women
- •Other systemic disorders 10.Patients on blood thinking agents.
结局指标
主要结局
Evaluation for prognosis with averaged PASI
时间窗: On 0 Day, 21st Day and 35th Day
次要结局
- 1. Dermatological Life Quality Index (DLQI)(2. Changes in the photographs of the affected site in fixed location and controlled illumination)