Efficacy of citalopram and sertraline in depression according to BDNF, IL-6, and cortisol levels
Phase 2
- Conditions
- Depression.Major depressive disorder, single episode, moderateF32.1
- Registration Number
- IRCT20090117001556N147
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Age between 18-60 years old
Based on DSM-V have a diagnosis of major depression (MDD) and their minimum severity of depression based on HDRS is 19
Exclusion Criteria
Any other mental disorder in another axis
Serious suicidal thoughts (<2 in suicidal HDRS section)
Psychosis
History of ECT in recent two months
History of mania and hypomania
Thyroid dysfunctions
History of cardiovascular disease
Diabetes
Autoimmune disorders
Presence of active infection
Neurologic disorders like epilepsy and Alzheimer's disease
Liver disease
Kidney disease
Pregnant or lactating women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of depression. Timepoint: Weeks 0 , 4 , 8. Method of measurement: By Hamilton Depression Rating Scale.
- Secondary Outcome Measures
Name Time Method