Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome; Evaluation by Incremental Load Test
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Incremental load test
研究概览
简要总结
Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity [body mass index (BMI) ≥30 kg/m2], chronic daytime hypercapnia (PaCO2 >45 mm Hg), and sleep-apnea in the absence of other known causes of hypercapnia. Respiratory system compliance decreases and resistance increases in OHS. This causes increase in work of breathing and oxygen cost of breathing, which may result in respiratory muscle fatigue. Increase in respiratory workload and increase in resistance to respiration is expected to decrease in respiratory muscle endurance (RME) in subjects with OHS.
详细描述
In the literature, studies evaluating RME in subjects with OHS are limited. No study has been found to evaluate RME using the incremental load test in subjects with OHS. Accordingly, it was aimed to evaluate and compare respiratory muscle endurance in subjects with OHS and a control group, and to determine factors associated with respiratory muscle endurance.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 24 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with OHS
- •Obese subjects (30 < body mass index < 40 kg/m2) with low risk of obstructive sleep apnea (STOP-BANG score < 3)
排除标准
- •Severe respiratory disease
- •Subjects with orthopeadic and/or neurologic disorders that could limit exercise tests
结局指标
主要结局
Incremental load test
时间窗: 1 day
Respiratory muscle endurance was evaluated by incremental load test. The incremental load test was performed using the electronic inspiratory loading device (PowerBreathe®-KHP2).
次要结局
- 6 minute walk test(1 day)
- Pittsburg Sleep Quality Index(1 day)
- Fatigue Severity Scale(1 day)
- EQ-5D Health-Related Quality of Life Questionnaire(1 day)
- Obesity and Weight Loss Quality of Life Instrument(1 day)
- Mouth pressure measurements(1 day)
- Epworth Sleepiness Scale(1 day)
研究者
Goksen Kuran Aslan
Assoc. Prof.
Istanbul University - Cerrahpasa (IUC)