Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome; Evaluation by Incremental Load Test
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity Hypoventilation Syndrome (OHS)
- Sponsor
- Istanbul University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Incremental load test
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity [body mass index (BMI) ≥30 kg/m2], chronic daytime hypercapnia (PaCO2 >45 mm Hg), and sleep-apnea in the absence of other known causes of hypercapnia. Respiratory system compliance decreases and resistance increases in OHS. This causes increase in work of breathing and oxygen cost of breathing, which may result in respiratory muscle fatigue. Increase in respiratory workload and increase in resistance to respiration is expected to decrease in respiratory muscle endurance (RME) in subjects with OHS.
Detailed Description
In the literature, studies evaluating RME in subjects with OHS are limited. No study has been found to evaluate RME using the incremental load test in subjects with OHS. Accordingly, it was aimed to evaluate and compare respiratory muscle endurance in subjects with OHS and a control group, and to determine factors associated with respiratory muscle endurance.
Investigators
Goksen Kuran Aslan
Assoc. Prof.
Istanbul University - Cerrahpasa (IUC)
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with OHS
- •Obese subjects (30 \< body mass index \< 40 kg/m2) with low risk of obstructive sleep apnea (STOP-BANG score \< 3)
Exclusion Criteria
- •Severe respiratory disease
- •Subjects with orthopeadic and/or neurologic disorders that could limit exercise tests
Outcomes
Primary Outcomes
Incremental load test
Time Frame: 1 day
Respiratory muscle endurance was evaluated by incremental load test. The incremental load test was performed using the electronic inspiratory loading device (PowerBreathe®-KHP2).
Secondary Outcomes
- 6 minute walk test(1 day)
- Pittsburg Sleep Quality Index(1 day)
- Fatigue Severity Scale(1 day)
- EQ-5D Health-Related Quality of Life Questionnaire(1 day)
- Obesity and Weight Loss Quality of Life Instrument(1 day)
- Mouth pressure measurements(1 day)
- Epworth Sleepiness Scale(1 day)