To investigate the clinical diagnostic potential of dysregulated microRNAs as early biomarkers in breast cancer patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Post surgical breast tumor tissue/blood will be collected for miRNAs expression, tumor suppressor genes, DNA repair genes and breast cancer receptor marker expression.
研究概览
简要总结
The dysregulation of epidermal growth factor receptors and hormonal receptors in breast cancer can be attributed to various factors, including the influence
of non-coding RNAs, particularly microRNAs.
These small RNA molecules play a pivotal role in post-
transcriptional gene regulation and have been implicated
as key players in breast cancer pathogenesis. In breast cancer, aberrant expression of miRNAs has been
observed, with many miRNAs found to be upregulated. These dysregulated miRNAs exert their influence by
modulating DNA repair activity and tumor suppressor
functions, thereby promoting cancer initiation and
progression and contributes to the molecular complexity
of breast cancer.
This study aims to delve into the intricate role of miRNAs
in the progression of breast cancer, elucidating their
influence on molecular markers, tumor suppressor genes, and DNA repair activity within breast cancer patient
samples. By analyzing a panel of miRNAs in these
patients, we seek to uncover potential biomarkers crucial
for diagnosing breast cancer early and distinguishing
between different subsets of the disease within a single
comprehensive study.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 80.00 Year(s)(—)
- 性别
- Female
入选标准
- •Female breast cancer patients.
- •Breast cancer patient age between 20-80 years.
- •Patient diagnosed through mammographic techniques.
- •All stages of diseases.
- •Surgery or mastectomy patients will be included.
- •With or without treatment patients will be included in this study.
排除标准
- 未提供
结局指标
主要结局
Post surgical breast tumor tissue/blood will be collected for miRNAs expression, tumor suppressor genes, DNA repair genes and breast cancer receptor marker expression.
时间窗: The samples will be processed and analyzed at 12 months
次要结局
未报告次要终点
研究者
PRAMOD KUMAR AVTI
POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH
