Melanocortin 4 Receptor Mutations and Obesity-associated Diseases
- Conditions
- Obesity
- Interventions
- Other: No intervention
- Registration Number
- NCT01849705
- Lead Sponsor
- University of Copenhagen
- Brief Summary
Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity.
Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.
The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 226
- Age 18-70 years
- Men and women
- BMI > 30 kg/m^2
- Uncontrolled type 2 diabetes
- Bariatric surgery
- Use of anti-obesity medication
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description All subjects No intervention No intervention
- Primary Outcome Measures
Name Time Method Blood pressure Baseline Systolic and diastolic blood pressure
- Secondary Outcome Measures
Name Time Method Obesity Baseline Obesity measured as BMI
Blood glucose Baseline Blood glucose measured at baseline
MC4R mutations Baseline MC4R mutations detected by sequencing of the coding region of the MC4R gene
Trial Locations
- Locations (1)
Department of Nutrition, Exercise and Sports, University of Copenhagen
🇩🇰Frederiksberg, Frederiksberg C, Denmark