A study on Prevention of Hypertensive Disorders of Pregnancy who have a history of severe hypertensive disorders of pregnancy -Pre-test for multi center trial

Not Applicable

Recruiting

• Conditions: Hypertensive Disorders of Pregnancy

• Registration Number: JPRN-UMIN000027270
• Lead Sponsor: Mie university hospital, Department of Obstetrics and Gynecology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-15
• Last Update Posted: 2023-10-17

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

1) 20 years of age or older
2) History of severe Hypertensive disorders of Pregnancy that required delivery prior to 34 weeks' gestation.
3) Gestational age between 12 + 0 and 16 + 6 weeks (The expected date of confinement is determined using the criteria of the guidelines for obstetrical practice in Japan 2014.)
4) Singleton pregnancy
5) For the test participation, it has consent is obtained in writing from the patient.

Exclusion Criteria

1)A history of allergy to tadalafil
2)Concurrent medications that interact adversely with tadalafil
3)Relative contraindication of tadalafil treatment due to renal disease.
4)Relative contraindication of tadalafil treatment due to liver disease.
5)Relative contraindication of tadalafil treatment due to uncontrolled arrhythmia, hypertension (BP >170/110 mmHg), and hypotension (BP <80/40 mmHg).
6)Fetus with suspected chromosomal disorder and/or multiple congenital anomalies.
7)Relative contraindication of tadalafil treatment due to retinitis pigmentosa, coagulation defect, active gastric and/or intestinal ulcer, and venous obstructive disease.
8)Attending physician decides to entry inappropriate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified