Correlates of the COPD Assessment Test (CAT) after stratification for GOLD stages and its response to pulmonary rehabilitation in patients with moderate to very severe COPD.

Completed

Conditions: COPD
emphysema or chronic bronchitis
10006436

Registration Number: NL-OMON39909

Lead Sponsor: CIRO+, expertisecentrum voor chronisch orgaanfalen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 873

Inclusion Criteria

1. Age 40-85 years
2. A diagnosis of COPD according to GOLD guidelines only applicable for COPD patients
3. Referral for assessment and pulmonary rehabilitation in Ciro+ by a chest physician only applicable for tertiary care patients.
4. Healthy, as judged by the investigator and determined by medical history and physical examination and post-bronchodilator FEV1/FVC * 70 only applicable for healthy controls

Exclusion Criteria

1. For healthy controls, primary, secondary and tertiary care patients: a history of asthma, kung cancer, sarcoidosis, tuberculosis, lung fibrosis, or any other significant respiratory disease; having undergone lung surgery (e.g. lung volume reduction, lung transplantation); any clinically relevant disease which in the opinion of the investigator may influence the results of the study
2. For primary, secondary and tertiary care patients only: moderate or severe exacerbation or pneumonia requiring systemic corticosteroids, antibiotics or hospitalisation during the last 4 weeks
3. For health controls only: COPD, chronic heart failure
4. Treatment by respiratory physician or tertiary care in primary care COPD patients
5. Treatment in tertiary care setting for secondary care COPD patients
6. Participation in an interventional clinical study during the past three months (for primary and secondary care patients).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the CAT scores of the COPD patients and the<br /><br>healthy controls. With the CAT scores we can examine the absolute and percent<br /><br>difference between COPD patients based on severity of their COPD. Also the<br /><br>absolute and percent difference between COPD patients and healthy controls<br /><br>shall be examined. For the tertiary care patients is the change in CAT score<br /><br>before and after rehabilitation important. CAT scores shall also be correlated<br /><br>with existing HRQL questionnaires, co-morbidity, and other potential<br /><br>confounders. </p><br>

Secondary Outcome Measures