Iron Long-Term Labelling Study Benin
- Conditions
- Iron Absorption
- Interventions
- Other: Eisensulfat LOMAPHARM 50 mg
- Registration Number
- NCT02979080
- Lead Sponsor
- Prof. Michael B. Zimmermann
- Brief Summary
Conventional indirect indicators of iron status, using serum and red blood cell biomarkers, are confounded by inflammation from common infections in sub-Saharan Africa, a region with a high prevalence of iron deficiency, making the assessment of iron balance and efficiency of iron intervention difficult. A potential reference method to quantify iron absorption and requirements using isotope dilution measurements in women living in areas with high burden of infection should be developed and validated within this project. The new method will allow accurate measurement of long term oral iron absorption and the estimation of iron requirements, potentially providing fundamental guidance for supplementation and fortification programs in sub-Saharan Africa. In a case series with four months' preventative iron supplementation intervention imbedded between a four months' control period prior intervention and a four months' control period after intervention, we will follow a group of 63 women. During the intervention period, the women will receive 50 mg Fe as ferrous sulfate tablets every day for 120 d. In total, the women will give 9 blood samples (day 1, 60 120, 150, 180, 210, 240, 300 and 360) for the de-termination of the isotopic composition and iron status biomarkers and 5 stool samples (day 1, 120, 180, 240 and 360) for the detection of soil transmitted helminths and gut inflammation. This design will allow the measurement of the isotopic iron dilution to assess the total oral iron absorption during the intervention period in comparison with the control periods without the administration of additional iron isotopes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 63
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Oral Iron Supplementation Eisensulfat LOMAPHARM 50 mg Eisensulfat LOMAPHARM 50 mg administration for 120 days
- Primary Outcome Measures
Name Time Method iron isotope composition in blood 1 year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Hôpital de zone de Natitingou
🇧🇯Natitingou, Atacora, Benin
Hôpital de zone d'Abomey-Calavi-Sô-Ava
🇧🇯Abomey-Calavi, Calavi, Benin