What Are the Effects of Sacubitril/Valsartan on the Heart Functions? Can It Increase the Ejection Fraction?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- Two dimensional left ventricular ejection fraction
研究概览
简要总结
Background:
Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and hospitalization. However, there is no prospective echocardiographic data describing the effects of sacubitril/valsartan on the heart functions and left ventricular (LV) reverse remodeling. Therefore, the aim of our study was to evaluate the effects of sacubitril/valsartan on the LV functions using two dimensional (2D), three dimensional (3D) echocardiography and the 3D strain parameters.
Methods:
In 100 patients with HF with reduced ejection fraction (HRrEF) who have indications for the use of sacubitril/valsartan as recommended by recent guidelines were prospectively enrolled. The basal 2D and 3D echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age is more than or equal 18 years old
- •Able to provide written informed consent
- •Indicated for the use of sacubitril/valsartan as recommended by the European Society of Cardiology (ESC) heart failure guidelines 2016
- •Left ventricular ejection fraction of 40% or less
排除标准
- •Cardiac resynchronization therapy (CRT) device implantation less than 3 months prior to the start of this study or CRT implantation intentions
- •Atrial fibrillation
- •Poor echocardiographic images
- •Sacubitril/valsartan treatment intolerance during the follow-up period
结局指标
主要结局
Two dimensional left ventricular ejection fraction
时间窗: 3 months
Two dimensional ejection fraction is measured as baseline and after 3 months follow-up
Three dimensional left ventricular ejection fraction
时间窗: 3 months
Three dimensional ejection fraction is measured as baseline and after 3 months follow-up
次要结局
- Three dimensional left ventricular volumes(3 months)
- Two dimensional left ventricular volumes(3 months)