Cortisol and the Formation of Intrusive Memories: An Experimental Approach With a Trauma Film Paradigm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Number of intrusive memories
研究概览
简要总结
Intrusive memories of traumatic events are core features of posttraumatic stress disorder (PTSD) but little is known about the neurobiological formation of intrusions. The aim of this study was to determine whether cortisol levels during an intrusion-inducing stressor influence subsequent intrusive memories.
详细描述
The investigators conducted an experimental, double-blind, placebo-controlled study in 60 healthy women. Prior to watching an established trauma film paradigm that induces short lasting intrusions, participants received a single dose of either 10 mg hydrocortisone or placebo. The number of consecutive intrusions of the trauma film, the mean vividness of the intrusions and the mean degree of distress evoked by the intrusions were assessed during the following seven days. Salivary cortisol and alpha-amylase were collected at seven time points prior to, and after the trauma film.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 34 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •healthy participants
- •German on a native level
排除标准
- •former or present DSM IV Axis I disorders
- •physical illnesses
- •any medication intake (except oral contraceptive)
- •history of sexual abuse or rape
- •pregnancy or lactation period
研究组 & 干预措施
Hydrocortisone and Stress Film
Administration of 10mg hydrocortisone before the trauma film.
干预措施: Stress Film (Behavioral)
Hydrocortisone and Stress Film
Administration of 10mg hydrocortisone before the trauma film.
干预措施: Hydrocortisone (Drug)
Placebo and Stress Film
Administration of placebo before the trauma film.
干预措施: Stress Film (Behavioral)
Placebo and Stress Film
Administration of placebo before the trauma film.
干预措施: Placebo (Drug)
结局指标
主要结局
Number of intrusive memories
时间窗: seven consecutive days
Measured with an intrusion diary
次要结局
- Vividness of intrusive memories(seven consecutive days)
- Degree of distress of intrusive memories(seven consecutive days)
研究者
Felicitas Rombold
Dipl.-Psych.
Charite University, Berlin, Germany