Cognitive Retraining and Brain Stimulation for Alcohol Use

Not Applicable

Completed

Brief Summary: The overarching goal of this study is to determine whether combined cognitive training and Transcranial Direct Current Stimulation (tDCS) reduces drinking in high-risk drinkers. To this end, specific study purposes are: 1) replicate previous findings that cognitive retraining reduces drinking levels, 2) test whether cognitive retraining can be enhanced with tDCS, and 3) investigate the neural changes that result from cognitive retraining and tDCS. We hypothesize that those participants who receive alcohol avoidance cognitive training will have greater reductions in drinking. In turn, those participants who receive a higher level of applied tDCS during alcohol avoidance response training will have better avoidance learning, as well as, a larger reduction in drinking behavior. Finally, those participants receiving a higher level of applied tDCS will have more neuronal response associated with alcohol avoidance during the brain imaging session.

Recruitment & Eligibility

Inclusion Criteria

Age 21-30 years
At least five binge drinking episodes (4+ drinks for men; 3+ drinks for women) for the past month
Alcohol Use Disorder Identification Test (AUDIT) score greater than 8
Right handed

Exclusion Criteria

History of treatment for alcohol dependence (AD) or desire for treatment
History of alcohol withdrawal
History of brain injury
Currently taking psychotropic medications (e.g. antidepressants, antipsychotics)
Female subjects who are pregnant
Evidence of recent illicit drug use on a urine screen
Left handed
Prior participation in a brain stimulation study
Implanted brain medical devices
Electromedical devices
Latex allergy

Primary Outcome Measures

Name	Time	Method
Drinks Per Drinking Day	Baseline	Number of standard drinks will be assessed using the Timeline Follow-back method to obtain the number of drinks consumed on each day since the last administration of the Timeline Follow-back. Drinks per drinking day will be the mean number of drinks consumed on days on which alcohol was consumed.
Alcohol Approach Bias	1 week after treatment	For each participant, bias is computed by taking the median response times to approaching alcohol pictures - response times to avoiding alcohol pictures, as measured with a pull or push of a joystick. Group means of these medians are presented as the outcome measure.

Secondary Outcome Measures

Name	Time	Method

Locations (1): The Mind Research Network and University of New Mexico Center on Alcoholism, Substance Abuse and Addiction
🇺🇸
Albuquerque, New Mexico, United States
The Mind Research Network and University of New Mexico Center on Alcoholism, Substance Abuse and Addiction
🇺🇸Albuquerque, New Mexico, United States