Modifying Alcohol Approach Motivations With tDCS and Cognitive Retraining
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Binge Drinking
- Sponsor
- The Mind Research Network
- Enrollment
- 77
- Locations
- 1
- Primary Endpoint
- Drinks Per Drinking Day
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The overarching goal of this study is to determine whether combined cognitive training and Transcranial Direct Current Stimulation (tDCS) reduces drinking in high-risk drinkers. To this end, specific study purposes are: 1) replicate previous findings that cognitive retraining reduces drinking levels, 2) test whether cognitive retraining can be enhanced with tDCS, and 3) investigate the neural changes that result from cognitive retraining and tDCS. We hypothesize that those participants who receive alcohol avoidance cognitive training will have greater reductions in drinking. In turn, those participants who receive a higher level of applied tDCS during alcohol avoidance response training will have better avoidance learning, as well as, a larger reduction in drinking behavior. Finally, those participants receiving a higher level of applied tDCS will have more neuronal response associated with alcohol avoidance during the brain imaging session.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 21-30 years
- •At least five binge drinking episodes (4+ drinks for men; 3+ drinks for women) for the past month
- •Alcohol Use Disorder Identification Test (AUDIT) score greater than 8
- •Right handed
Exclusion Criteria
- •History of treatment for alcohol dependence (AD) or desire for treatment
- •History of alcohol withdrawal
- •History of brain injury
- •Currently taking psychotropic medications (e.g. antidepressants, antipsychotics)
- •Female subjects who are pregnant
- •Evidence of recent illicit drug use on a urine screen
- •Left handed
- •Prior participation in a brain stimulation study
- •Implanted brain medical devices
- •Electromedical devices
Outcomes
Primary Outcomes
Drinks Per Drinking Day
Time Frame: Baseline
Number of standard drinks will be assessed using the Timeline Follow-back method to obtain the number of drinks consumed on each day since the last administration of the Timeline Follow-back. Drinks per drinking day will be the mean number of drinks consumed on days on which alcohol was consumed.
Alcohol Approach Bias
Time Frame: 1 week after treatment
For each participant, bias is computed by taking the median response times to approaching alcohol pictures - response times to avoiding alcohol pictures, as measured with a pull or push of a joystick. Group means of these medians are presented as the outcome measure.