EUCTR2007-007813-35-GB
Active, not recruiting
Not Applicable
Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Cemented Total Knee Replacement (TRANX-K). - TRANX-K
niversity Hospital of North Tees and Hartlepool0 sitesMarch 26, 2008
ConditionsIn this study Tranexamic acid efficacy in reducing blood loss will be investigated in total knee replacement.Tranexamic acid will be applied topically to the exposed tissue around the knee joint prior to the wound closure and tourniquet release. It is anticipated that this method of administration will be quicker, easier and have less systemic side effect.MedDRA version: 9.1Level: LLTClassification code 10023227Term: Joint replacement
DrugsCyklokapron
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- In this study Tranexamic acid efficacy in reducing blood loss will be investigated in total knee replacement.Tranexamic acid will be applied topically to the exposed tissue around the knee joint prior to the wound closure and tourniquet release. It is anticipated that this method of administration will be quicker, easier and have less systemic side effect.
- Sponsor
- niversity Hospital of North Tees and Hartlepool
- Status
- Active, not recruiting
- Last Updated
- 14 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Undergoing unilateral primary cemented total knee replacement.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range
Exclusion Criteria
- •1\.Undergoing unilateral primary total knee replacement for trauma or tumour.
- •2\.Allergic to Tranexamic acid.
- •3\.Bleeding tendency (e.g. Haemophilic and ITP).
- •4\.Warfarin, treatment dose of LMWH or conventional heparin).
- •5\.History of DVT and pulmonary embolism.
- •6\.Female subjects of child bearing potential must have a negative pregnancy test.
Outcomes
Primary Outcomes
Not specified
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