The effect of addition of Spironolactone to Enalapril on urinary albumin loss in diabetic patients.
Not Applicable
- Conditions
- Proteinuria due to diabetic nephropathy in diabetes type 2.Non-insulin dependent diabetes mellitus
- Registration Number
- IRCT201109067483N1
- Lead Sponsor
- Qazvin Metabolic Diseases Research Centre(QMDRC), Qazvin university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Diabetic nephropathy as micro-albuminuria, More than 18 years old, Less than 80 years old
Exclusion criteria: Serum creatinine more than 2mg/dl, Serum Potassium more than 5.5 mmol/dl at any stage of the study, Cardiac ejection fraction less than 35%
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rine Albumin. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Urine Creatinine. Timepoint: at the beginning and the end of the study. Method of measurement: by laboratory kit.;Albumin on creatinine ratio. Timepoint: at the beginning and the end of the study. Method of measurement: by division of numeric amount of albumin on numeric amount of creatinine.
- Secondary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by sphygmomanometer (mmHg).;Serum potassium. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: by laboratory kit (mmol/dl).;Glumerular filteration ration (GFR). Timepoint: at the beginning and the end of the study. Method of measurement: by MDRD method (Modification of Diet in Renal Disease).;Body weight. Timepoint: at the beginning and the end of the study. Method of measurement: medical weighing scale(Kg).;Diastolic blood pressure. Timepoint: At the beginning , after the 6th week and at the end of the study. Method of measurement: Sphygmomanometer (mmHg).