Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Fanconi's Anemia

Fairview University Medical Center2 个研究点分布在 1 个国家开始时间: 2000年3月1日最近更新: 2005年6月24日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Fairview University Medical Center
试验地点: 2

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

OBJECTIVES:

I. Determine the effectiveness of moderate dose cyclophosphamide and total lymphoid radiotherapy in terms of improving the survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with Fanconi's aplastic anemia.

详细描述

PROTOCOL OUTLINE: Patients receive cyclophosphamide IV over 2 hours on day -6 through -3 and total lymphoid radiotherapy on day -1. Patients undergo allogeneic bone marrow transplantation on day 0.

Patients are followed for at least 100 days.

研究设计

研究类型: Interventional
主要目的: Treatment

入排标准

年龄范围: 0 Years 至 54 Years（Child, Adult）
性别: All
接受健康志愿者: 否

入选标准

•Diagnosis of severe aplastic anemia with the typical phenotype of Fanconi's anemia: Short stature Hypoplastic radii Skin pigmentation Renal anomalies Chromosomal fragility
•Family history of Fanconi's anemia
•Histocompatible related donor No evidence of excessive in vitro chromosome fragility typical of Fanconi's anemia Normal CBC and bone marrow

排除标准

未提供

研究者

发起方

Fairview University Medical Center

申办方类型

Other

研究点 (2)

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