The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study
Not Applicable
Completed
- Conditions
- Acute Kidney Injury
- Interventions
- Drug: atrovastatinDrug: Placebo
- Registration Number
- NCT01909739
- Lead Sponsor
- Yonsei University
- Brief Summary
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- patients over the age of 20 scheduled for valvular heart surgery
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Exclusion Criteria
- Current statin use
- Left ventricular ejection fraction < 30%
- Preexisting congestive heart failure
- Severe coronary artery disease
- Hemodynamically unstable arrhythmia
- Cardiogenic shock during perioperative period
- Ventricular assist device
- Severe renal dysfunction (eGFR < 15 ml/min per 1.73 m2)
- History of liver disease or elevated serum transaminases
- History of rhabdomyolysis or elevated creatinine kinase
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Statin group atrovastatin - Placebo group Placebo -
- Primary Outcome Measures
Name Time Method Comparison of postoperative renal function with or without statin in patients undergoing valvular heart surgery renal function change from 24-hour after surgery to 120-hour after surery BUN/Cr cystatin C eGFR urine output incidence of acute kidney injury(based on the AKIN criteria)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of