Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults

Not Applicable

Completed

• Conditions: Transcutaneous Electrical Nerve Stimulation
• Interventions: Device: transcutaneous electrical nerve stimulation, TENS

• Registration Number: NCT02077595
• Lead Sponsor: Chang Gung University

Brief Summary

Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Study First Submitted: 2014-02-11
• Status Verified: 2014-03
• Study First Submitted QC: 2014-03-03
• Last Update Submitted: 2014-03-03
• Study First Posted: 2014-03-04
• Last Update Posted: 2014-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy adults

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
120Hz alternating current stimulation group	transcutaneous electrical nerve stimulation, TENS	-
5Hz alternating current stimulation group	transcutaneous electrical nerve stimulation, TENS	-
sham alternating current stimulation group	transcutaneous electrical nerve stimulation, TENS	-

Primary Outcome Measures

Name	Time	Method
intracortical facilitation, ICF	Baseline,Baseline,2 hours, 2.5 hours,and 3 hours	Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Motor evoked potential	Baseline	measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.
Intracortical inhibition, ICI	Baseline,2 hours, 2.5 hours,and 3 hours	Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan