comparison of effect of Intraperitoneal injection of Dexmedetomidineor Fentanyl in addition to Ropivacaine forpostoperative pain management after LaparoscopicCholecystectomy

Completed

Brief Summary: Laparoscopic cholecystectomy (LC) is the most accepted surgical technique for cholelithiasis as compared to open cholecystectomy. Although laparoscopic cholecystectomy (LC) results in less pain than open chole-cystectomy, it is not a pain-free procedure.Multimodal analgesia including parenteral opioids, nonsteroidal anti-inflammatory drugs (NSAID) or local infiltration with local anesthetics is used to reduce pain. Despite their efficacy, all parenteral medications have associated adverse effectsIntraperitoneal injections of local anaesthetic have been proposed to minimize postoperative pain after laparoscopic surgeries. Adjuvants are often added to local anaesthetics for nerve blocks to prolong its anaesthetic effects. Alpha 2 agonists such as clonidine or dexmedetomidine and opioids like fentanyl combined with Bupivacaine has shown to increase the duration of anaesthesia significantly.Ropivacaine newer analgesic, with better toxicity profile compared with other local anaesthetic, such as Bupivacaine, is considered the safest, long acting local anaesthetic available in market.Since there are a few studies which have compared the nociceptive effects of intraperitoneal fentanyl to intraperitoneal dexmedetomidine, Hence the present study was undertaken to compare the effects of intraperitoneal bupivacaine with dexmedetomidine or fentanyl as adjuvants, in patients undergoing ambulatory laparoscopic cholecystectomy

Recruitment & Eligibility

Inclusion Criteria

1.Patients Posted For Elective Laparoscopic Cholecystectomy Of ASA I AND ASA II 2.Patients Of Age 18-60 Years Of Either Sex.

Exclusion Criteria

Pregnancy Patients With Cardiac/Renal/Psychiatric/Coagulation Disorder Patient Refusal To Give Consent Laproscopic Converted To Open Cholecystectomy.

Primary Outcome Measures

Name	Time	Method
Time duration of first rescue analgesia	within 24 hrs

Secondary Outcome Measures

Name	Time	Method
Effect on NRS in post-operative duration.	Effects on post-operative

Locations (1): Hind Institute of Medical Sciences
🇮🇳
Sitapur, UTTAR PRADESH, India
Hind Institute of Medical Sciences
🇮🇳Sitapur, UTTAR PRADESH, India
Dr Ranjana bhadauria
Principal investigator
9458237267
rbhadauria14@gmail.com
DR Sudhir Kumar Rai
Principal investigator
8840007687
sudhir.rai17@gmail.com