Association Between Pre-operative Use of Non-selective Beta-blockers With the Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation : a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,092
- 主要终点
- Kaplan-Meier survival analysis of HCC recurrence at 5-year follow-up
研究概览
简要总结
The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver transplantation (LT) for treating hepatocellular carcinoma.
The main question[s] it aims to answer are:
- Is the usage of non-selective beta-blocker associated with decreased recurrence of hepatocellular carcinoma following liver transplantation?
- Is the usage of non-selective beta-blocker associated with all-cause mortality following liver transplantation?
Researchers will compare the NSBB group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •Underwent liver transplantation for treating hepatocellular carcinoma
- •Between Jan. 2008 - May. 2022
排除标准
- •Pediatric patients (Age under 18 years)
- •Re-transplantation
- •Multi-organ transplantation
研究组 & 干预措施
NSBB group
The NSBB group was defined as those who received NSBBs for at least 30 consecutive days within the 3 months prior to LT.
干预措施: Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use (Drug)
结局指标
主要结局
Kaplan-Meier survival analysis of HCC recurrence at 5-year follow-up
时间窗: Baseline and 5-year follow-up
HCC recurrence, which was diagnosed based on pathological or radiographic evidence of new lesions consistent with HCC, and recurrence-free survival was collected and compared using Kaplan-Meier survival analysis.
Multivariate Cox regression analysis of HCC recurrence at 5-year follow-up
时间窗: Baseline and 5-year follow-up
Multivariate Cox regression analysis was performed to identify the risk factors for HCC recurrence.
次要结局
- Kaplan-Meier survival analysis of overall survival at 5-year follow-up(Baseline and 5-year follow-up)
- Multivariate Cox regression analysis of overall survival at 5-year follow-up(Baseline and 5-year follow-up)
研究者
Jun-Gol Song
Professor
Asan Medical Center