Diffuse Noxious Inhibitory Controls in chronic cough: a randomised, four-way cross-over study of 20 healthy subjects and 20 patients with chronic cough

niversity Hospitals of South Manchester NHS Foundation Trust (UK)0 个研究点目标入组 40 人开始时间: 2011年4月7日最近更新: 2017年2月27日

试验速览

暂无简介。

•Healthy volunteers:
•1. Aged over 18 years old, either sex
•2. Normal lung function
•3. No current or past history of chronic cough or chronic respiratory illness
•4. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches
•5. No current or past history of psychiatric illness
•6. No current history of reflux disease or post-nasal drip syndrome
•Chronic cough patients:
•1. Aged over 18 years old, either sex
•2. Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease
•3. Normal chest x-ray
•4. Normal lung function
•5. Can safely omit long-acting bronchodilators (if taking)

•1. Recent upper respiratory tract infection (less than 4 weeks)
•2. Pregnancy or breastfeeding
•3. Use of angiotensin converting enzyme (ACE) inhibitors
•4. Any centrally acting medication which could alter the sensitivity of the cough reflex
•5. History of drug or alcohol abuse
•6. Current smoker or ex-smoker with greater than 10 pack year smoking history

发起方

niversity Hospitals of South Manchester NHS Foundation Trust (UK)