A Prospective Study of Acute Nontraumatic Chest Pain - Warning and Classification
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 10,000
- Locations
- 1
- Primary Endpoint
- Adverse events
Study Overview
Brief Summary
Acute non-traumatic chest pain is one of the common causes of presentation in emergency patients, but the causes of acute non-traumatic chest pain are complex, the severity of the condition varies greatly, and the specificity of symptoms is not high. Machine learning and intelligent auxiliary models can greatly shorten the time of clinical decision-making, and improve the accuracy of etiological diagnosis in patients with chest pain, reduce the rate of misdiagnosis and missed diagnosis, and provide a clear direction for further treatment.
Detailed Description
Prospective observational studies used outpatient and follow-up information to construct an auxiliary early warning model of acute non-traumatic chest pain based on federated learning, and optimized the accuracy of early warning models through retrospective and prospective studies of large cohort data, and established an efficient and stable early warning and classification model for acute non-traumatic chest pain.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥ 18 years
- •Symptom onset or worsening within 24 hours before presentation, with a chief complaint of acute chest pain meeting the broad definition of chest pain (2021 AHA)
- •Presentation to the emergency department, with a clinical diagnosis consistent with non-traumatic chest pain
- •Signed informed consent
Exclusion Criteria
- •traumatic chest pain
- •systemic pain caused by malignant tumors or rheumatic diseases involving the chest
- •Patients were lost to follow-up
Arms & Interventions
No cardiovascular adverse and cerebrovascular events (MACCE) occurred during the 1-month period
No cardiovascular and cerebrovascular adverse events (MACCE)，which included cardiovascular death, all-cause mortality, nonfatal myocardial infarction, refractory angina, new onset heart failure and stroke. Follow-up visits are conducted by in-person or telephone and registration is carried out.
Intervention: Clinical evaluation, laboratory and cardiac imaging results, medication, surgery, and any hospitalization (Combination Product)
Group of major cardiovascular and cerebrovascular adverse events (MACCE) occurring during 1 month
Cardiovascular and cerebrovascular adverse events occur, the rest of the same as in the previous group
Intervention: Clinical evaluation, laboratory and cardiac imaging results, medication, surgery, and any hospitalization (Combination Product)
Outcomes
Primary Outcomes
Adverse events
Time Frame: 30 days after presenting to the emergency departments(ED)
The primary outcome was a composite of adjudicated major adverse cardiovascular and cerebrovascular events (MACCE), which included cardiovascular death, all-cause mortality, nonfatal myocardial infarction, refractory angina, new onset heart failure and stroke.
Secondary Outcomes
No secondary outcomes reported
Investigators
Xiao-nan He
Chief physician of Emergency and Critical Care Center of Beijing Anzhen Hospital
Beijing Anzhen Hospital