Correlation Between Serum Uric Acid and Pulmonary Hypertension in Obstructive Sleep Apnea Syndrome

Not Applicable

Completed

• Conditions: Obstructive Sleep Apnea
• Interventions: Diagnostic Test: polysomnography

• Registration Number: NCT05967754
• Lead Sponsor: Alexandria University

Brief Summary

This study aimed to correlate serum uric acid levels and PAH in OSAHS patients.

Detailed Description

Obstructive sleep apnea-hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, that accompanies OSAHS increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension.

AIM OF THE WORK This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI \< 15), moderate OSA (15 ≤ AHI \< 30), and severe (30 ≤ AHI \< 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and Pulmonary artery systolic pressure calculation was done.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2020-10-01
• Study Completion: 2020-12-01
• Status Verified: 2023-07
• Study First Submitted: 2023-07-15
• Study First Submitted QC: 2023-07-22
• Last Update Submitted: 2023-07-22
• Study First Posted: 2023-08-01
• Last Update Posted: 2023-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Clinical diagnosis of OSAHS by overnight polysomnography (AHI ≥ 5/ hr)
• ≥18 years old.

Exclusion Criteria

• Other sleep disorders as narcolepsy or hypersomnia were excluded as well as Patients with neuropsychiatric disorders.
• Hemodynamically unstable patients
• Patients with other chronic respiratory or cardiac diseases
• Patients with other known causes of pulmonary hypertension
• Patients with any disease or on medication that could alter excretion or urinary metabolism of uric acid such as Excessive uric acid production

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with Obstructive sleep Apnea	polysomnography	Patients with Obstructive sleep Apnea

Primary Outcome Measures

Name	Time	Method
This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.	one Year	This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.

Trial Locations

Locations (1)

Rania Ahmad Sweed; 🇪🇬 Alexandria, Egypt