Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- LBM_DEXA
研究概览
简要总结
Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).
Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.
详细描述
Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •non-dialyzed patients with CKD stage 3-5
- •clinical stable
- •a willingness to be examined with all measurements being taken simultaneously.
排除标准
- •systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
- •severe edema within one month prior to the study
- •chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
- •taking immunosuppressive agents and anti-inflammatory medication chronically
结局指标
主要结局
LBM_DEXA
时间窗: between March 1st, 2014 and December 1st, 2015
lean body mass measured by dual-energy x-ray absorptiometry (DEXA)
次要结局
未报告次要终点
研究者
Dong Jie
Clinical Professor of Institute of Nephrology, Division of Renal
Peking University First Hospital