Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease
- Conditions
- Lean Body MassChronic Kidney Diseases
- Registration Number
- NCT04074278
- Lead Sponsor
- Peking University First Hospital
- Brief Summary
Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).
Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.
- Detailed Description
Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- non-dialyzed patients with CKD stage 3-5
- clinical stable
- a willingness to be examined with all measurements being taken simultaneously.
- systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
- severe edema within one month prior to the study
- chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
- taking immunosuppressive agents and anti-inflammatory medication chronically
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method LBM_DEXA between March 1st, 2014 and December 1st, 2015 lean body mass measured by dual-energy x-ray absorptiometry (DEXA)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Renal Division and Institute of Nephrology, Peking University First Hospital
🇨🇳Beijing, Beijing, China