Metabolism of secondary plant compounds and influence on dental health using removable bovine tooth enamel samples
- Conditions
- K02.9Dental caries, unspecified
- Registration Number
- DRKS00026713
- Lead Sponsor
- niversitätsklinikum Schleswig-Holstein Campus Kiel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 30
Visible soft and hard plaque
<18.5 or >29.5 kg/m², metabolic or endocrine diseases, malabsorption syndrome, allergies, smoking, alcohol and drug abuse, use of supplements (food additives), antidepressants, antibiotics, fructose intolerance, the presence of a defibrillator or pacemaker, a nickel allergy, known allergies to the study materials used, an MRI examination scheduled during the study period, reflux disease, bulimia, diseases (such as HIV, hepatitis or diabetes) and epilepsy
Erosions or carious defects on the teeth requiring treatment, professional dental cleaning less than 4 weeks ago, a periodontal screening index (PSI) >2, no stable occlusion, orthodontic treatment carried out at the time of the study, wearing an occlusal splint ('grinding splint') and no sufficient number of teeth, i.e. no terminal molar in the fourth or third quadrant and more than 2 missing teeth per quadrant.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Observation of caries development on the bovine enamel samples after 14 days with the aid of microscopic and scanning electromicroscope evaluation.<br>Depth determination of (de)mineralization analogous to caries development
- Secondary Outcome Measures
Name Time Method pH measurement, metabolome, microbiome,<br>Blood glucose value