Factors Affecting Timing of Hypothyroidism Following Radioactive Iodine Therapy Patients With Graves Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Assiut University
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- predictive factors of early hypothyroidism after RAI therapy
Study Overview
Brief Summary
The purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after RAI therapy in Graves' disease.
Detailed Description
Hyperthyroidism is a clinical syndrome caused by increased thyroid hormone in the blood, it can lead to multiple complications, including cardiac, hepatic, and hematologic system complications. More than 80% of hyperthyroidism are caused by Graves' disease (GD). 3% of women and 0.5% of men may suffer GD in their lifetime [1].
Radioactive iodine (RAI) therapy is an important treatment option for Graves' disease (GD), the main side effect of RAI treatment is hypothyroidism, and the factors resulting in hypothyroidism are still controversial [2]. Male gender, smaller thyroid weight, higher thyroid-stimulating hormone, and smaller thyroid volume are Suggested to be the main risk factors for early hypothyroidism [2]-[3].
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Other
Eligibility Criteria
- Ages
- 13 Years to 70 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Graves' disease patients after one year of RAI therapy .
- •Suppressed serum thyrotropin (TSH) <0.55 µU/ml , elevated serum free triiodothyronine (FT3) > 6.5 pmol/L , free thyroxin FT4 >22.7 pmol/L .
Exclusion Criteria
- •Patients with other causes of hyperthyroidism , such as toxic multinodular goiter and single toxic adenoma
- •Thyroid cancer
- •Recurrent GD
- •Previous Thyroid surgery
- •Patients can't complete the follow -up within 6 months.
Outcomes
Primary Outcomes
predictive factors of early hypothyroidism after RAI therapy
Time Frame: 1 year
Retrospective study from 2013 to 2022 to analyze the correlation between clinical, demographic\& and laboratory data and incidence of hypothyroidism by measuring thyroid function tests
Secondary Outcomes
- the incidence of hypothyroidism within 1 year(10 years)
Investigators
Aya Abdel-Baset Ahmed Ali Alsanory
Resident in nuclear medicine departement (South Egypt Cancer institute)
Assiut University