NCT00250211已完成1 期
Multimodality Functional Imaging (MRS and Tumor Perfusion) Predicts Tumor Migration, Invasiveness, and Patterns of Failure of Human Glioblastoma Treated With Concurrent Radiation Therapy and Temozolomide
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- determine tumor response and pattern of failure using functional MRI imaging
研究概览
简要总结
The purpose of this study is to learn whether 3 tesla (3T) MRI functional imaging will map a tumor more accurately allowing a more targeted delivery of radiation. The investigators hope to learn whether tomotherapy will be able to deliver higher radiation doses safely to the tumor while sparing the surrounding normal tissue.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed glioblastoma multiforme
- •Ages 18-65
- •Karnofsky Performance Scale (KPS) equal to or less than 70
- •Minimal neurological deficit
- •Eligible for concurrent temozolomide chemotherapy
排除标准
- •Prior radiation therapy to hand or neck area, chemotherapy, or radiosensitizer
结局指标
主要结局
determine tumor response and pattern of failure using functional MRI imaging
时间窗: Study completion
time to disease progression
时间窗: Study completion
次要结局
- survival
- distinguish residual tumor from treatment-related necrosis(study completion)
- acute late toxicity of tomotherapy and hypofractionation
研究者
研究点 (2)
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