PARAN-Study: Association between chronic periodontitis and anemia of inflammation geriatric inpatients

• Conditions: D63; K05; D64.8; Anaemia in chronic diseases classified elsewhere; Gingivitis and periodontal diseases; Other specified anaemias

• Registration Number: DRKS00024446
• Lead Sponsor: Poliklinik für Zahnerhaltung und Parodontologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-11
• Study Completion: 2022-10-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Ability to give independent consent
Sufficient knowledge of German
Absence of exclusion criteria

Exclusion Criteria

patients with acute and chronic inflammation (CRP >5mg/dl)
Patients with active tumor disease requiring treatment,
infection requiring treatment,
actual antibiotic treatment
chronic inflammatory disease such as rheumatoid arthritis, chronic inflammatory bowel disease
osteomyelitis
previous (within 2 weeks) apoplectic insult with lysis treatment
glomerular filtration rate <30 ml/min
dialysis requirement or coronary heart disease requiring intervention

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oral health screening (PBI, Quigley-Hein index, PSI/CPITN) and collection of a sulcus sample (aMMP8 and calprotectin) are performed on the examination date for geriatric patients. These data will be statistically analyzed with the routinely recorded blood parameters (leukocytes, erythrocytes, hemoglobin, hematocrit, RDW platelets, MCV, MCHC, MCH, CRP, transferrin saturation, ferritin, C-reactive protein, transferrin, cobalamin (VitB12), and folic acid) and geriatric parameters from the patient record (Barthel index, current medication, principal diagnosis, and comorbidities). <br><br><br>The aim of the study is to investigate whether the highly prevalent chronic periodontitis in the group of geriatric patients contributes to chronic inflammatory anemia and thus could serve as a risk indicator.

Secondary Outcome Measures

Name	Time	Method
- Sulcus fluid calprotectin and aMMP8 levels correlate with each other and with laboratory values of inflammatory anemia. <br><br>- To assess whether the degree of periodontitis is associated with an increase in the RDW value (red cell distribution width).<br><br>- Assess whether the degree of periodontitis is associated with MCV heterogeneity.<br><br>- Assess whether decreased MCV and increased RDW are associated with periodontitis.