Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer
- Conditions
- Radiation ToxicityOral ComplicationsDrug/Agent Toxicity by Tissue/OrganLung Cancer
- Interventions
- Biological: filgrastimRadiation: radiation therapy
- Registration Number
- NCT00003313
- Lead Sponsor
- Radiation Therapy Oncology Group
- Brief Summary
RATIONALE: Amifostine may be an effective treatment for the toxic side effects caused by radiation therapy and chemotherapy. It is not yet known whether chemotherapy and radiation therapy are more effective with or without amifostine for non-small cell lung cancer.
PURPOSE: Randomized phase III trial to determine the effectiveness of amifostine in treating patients who have stage II or stage III non-small cell lung cancer that cannot be surgically removed and who are undergoing chemotherapy and radiation therapy.
- Detailed Description
OBJECTIVES: I. Evaluate whether the addition of the radioprotector amifostine can reduce the incidence and severity of non-hematologic toxicity, specifically esophagitis and pneumonitis, during concurrent hyperfractionated radiotherapy and chemotherapy (with paclitaxel and carboplatin) in patients with stage II, IIIA, or IIIB non-small cell lung cancer. II. Evaluate the differences in quality of life and symptom distress, specifically dysphagia, between patients receiving amifostine and those not receiving amifostine. III. Evaluate the relationship of tobacco use and alcohol use during treatment to appraisals of quality of life and symptom distress, specifically esophagitis, in the two groups. IV. Evaluate the efficacy of induction therapy with paclitaxel and carboplatin followed by concurrent chemotherapy and hyperfractionated radiotherapy in these patients.
OUTLINE: This is an open-label treatment and randomized supportive care study. Patients are stratified according to disease stage (II vs IIIA vs IIIB), Karnofsky performance status (90-100% vs 70-80%), and age (70 and under vs over 70). Patients are randomized to one of two treatment arms. Arm I: Patients receive paclitaxel IV over 3 hours on days 1 and 22 and over 1 hour weekly for 6 weeks beginning on day 43. Patients receive carboplatin IV over 30 minutes immediately after each paclitaxel dose. Patients receive filgrastim (G-CSF) subcutaneously for 10-14 days after each of the first two paclitaxel and carboplatin doses. Radiotherapy begins on day 43 and is administered twice daily for 5 days per week for 6 weeks. Beginning on day 43, patients receive amifostine IV over 5-7 minutes 4 days a week for 6 weeks. Arm II: Patients receive treatment as in arm I without amifostine. Quality of life is assessed at baseline, before chemoradiation (after 2 courses of induction chemotherapy), the last week of chemoradiation (week 6), and at the 6-week follow-up visit. Patients are followed at 1 month, every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 244 patients (122 per treatment arm) will be accrued for this study within 38 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 243
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm 1 radiation therapy Radiation therapy and chemotherapy + Amifostine Arm 2 filgrastim Radiation therapy and chemotherapy alone Arm 1 filgrastim Radiation therapy and chemotherapy + Amifostine Arm 1 paclitaxel Radiation therapy and chemotherapy + Amifostine Arm 1 amifostine trihydrate Radiation therapy and chemotherapy + Amifostine Arm 2 radiation therapy Radiation therapy and chemotherapy alone Arm 1 carboplatin Radiation therapy and chemotherapy + Amifostine Arm 2 carboplatin Radiation therapy and chemotherapy alone Arm 2 paclitaxel Radiation therapy and chemotherapy alone
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (264)
North Mississippi Medical Center/Cancer Center
🇺🇸Tupelo, Mississippi, United States
RMH Regional Canter Center
🇺🇸Harrisonburg, Virginia, United States
Greater Baltimore Medical Center and Cancer Center
🇺🇸Baltimore, Maryland, United States
Hahnemann University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Cancer Institute
🇺🇸Pittsburgh, Pennsylvania, United States
Western Pennsylvania Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
New York Medical College
🇺🇸Valhalla, New York, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
Sylvester Cancer Center, University of Miami
🇺🇸Miami, Florida, United States
CCOP - Southern Nevada Cancer Research Foundation
🇺🇸Las Vegas, Nevada, United States
Huntsville Hospital System
🇺🇸Huntsville, Alabama, United States
Comprehensive Cancer Institute of Huntsville
🇺🇸Huntsville, Alabama, United States
Jonsson Comprehensive Cancer Center, UCLA
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center and Hospital
🇺🇸Los Angeles, California, United States
University of California San Diego Cancer Center
🇺🇸La Jolla, California, United States
Veterans Affairs Medical Center - Long Beach
🇺🇸Long Beach, California, United States
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
Glendale Memorial Hospital and Health Center
🇺🇸Glendale, California, United States
Huntington Cancer Center
🇺🇸Pasadena, California, United States
Memorial Hospital Cancer Center
🇺🇸Colorado Springs, Colorado, United States
Saint Mary's Hospital and Medical Center
🇺🇸Grand Junction, Colorado, United States
CCOP - Christiana Care Health Services
🇺🇸Wilmington, Delaware, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States
Radiation Therapy Associates - Fort Myers
🇺🇸Fort Myers, Florida, United States
Lykes Center for Radiation Therapy
🇺🇸Clearwater, Florida, United States
University of Florida Health Science Center
🇺🇸Gainesville, Florida, United States
Veterans Affairs Medical Center - Miami
🇺🇸Miami, Florida, United States
CCOP - Mount Sinai Medical Center
🇺🇸Miami Beach, Florida, United States
Health First Holmes Regional Medical Center
🇺🇸Melbourne, Florida, United States
Florida Radiation Oncology Group
🇺🇸Orange Park, Florida, United States
Baptist Hospital of Miami
🇺🇸Miami, Florida, United States
Bay Medical Center
🇺🇸Panama City, Florida, United States
Gulf Coast Cancer Treatment Center
🇺🇸Panama City, Florida, United States
Sarasota Radiation and Medical Oncology Center
🇺🇸Sarasota, Florida, United States
Regional Radiation Oncology Center at Rome
🇺🇸Rome, Georgia, United States
Emory University Hospital - Atlanta
🇺🇸Atlanta, Georgia, United States
Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
Medical Center/John B. Amos Community Cancer Center
🇺🇸Columbus, Georgia, United States
Northwest Community Hospital
🇺🇸Arlington Heights, Illinois, United States
MBCCOP - Hawaii
🇺🇸Honolulu, Hawaii, United States
CCOP - Central Illinois
🇺🇸Decatur, Illinois, United States
Ingalls Memorial Hospital
🇺🇸Harvey, Illinois, United States
Methodist Medical Center of Illinois
🇺🇸Peoria, Illinois, United States
Lutheran General Cancer Care Center
🇺🇸Park Ridge, Illinois, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
Bloomington Hospital
🇺🇸Bloomington, Indiana, United States
Veterans Affairs Medical Center - Indianapolis (Roudebush)
🇺🇸Indianapolis, Indiana, United States
Clarion Health Partners Inc.
🇺🇸Indianapolis, Indiana, United States
Wendt Regional Cancer Center of Finley Hospital
🇺🇸Dubuque, Iowa, United States
Holden Comprehensive Cancer Center at The University of Iowa
🇺🇸Iowa City, Iowa, United States
Veterans Affairs Medical Center - Lexington
🇺🇸Lexington, Kentucky, United States
Central Baptist Hospital
🇺🇸Lexington, Kentucky, United States
Albert B. Chandler Medical Center, University of Kentucky
🇺🇸Lexington, Kentucky, United States
Mary Bird Perkins Cancer Center
🇺🇸Baton Rouge, Louisiana, United States
Merle M. Mahr Cancer Center
🇺🇸Madisonville, Kentucky, United States
Romagosa Radiation Oncology Center
🇺🇸Lafayette, Louisiana, United States
MBCCOP - LSU Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Tulane University School of Medicine
🇺🇸New Orleans, Louisiana, United States
Maine Medical Center
🇺🇸Portland, Maine, United States
Anne Arundel Oncology Center
🇺🇸Annapolis, Maryland, United States
CCOP - Ochsner
🇺🇸New Orleans, Louisiana, United States
Harbor Hospital Center
🇺🇸Baltimore, Maryland, United States
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
CCOP - Cancer Research for the Ozarks
🇺🇸Springfield, Missouri, United States
St. Louis University Health Sciences Center
🇺🇸Saint Louis, Missouri, United States
Cancer Research for the Ozarks
🇺🇸Springfield, Missouri, United States
Herbert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
Catawba Memorial Hospital
🇺🇸Hickory, North Carolina, United States
Christ Hospital
🇺🇸Cincinnati, Ohio, United States
University Hospitals of Cleveland
🇺🇸Cleveland, Ohio, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
CCOP - Dayton
🇺🇸Kettering, Ohio, United States
CCOP - Toledo Community Hospital Oncology Program
🇺🇸Toledo, Ohio, United States
St. John Health System
🇺🇸Tulsa, Oklahoma, United States
Geisinger Medical Center
🇺🇸Danville, Pennsylvania, United States
Delaware County Memorial Hospital
🇺🇸Drexel Hill, Pennsylvania, United States
Fitzgerald Mercy Hospital
🇺🇸Darby, Pennsylvania, United States
Reading Hospital and Medical Center
🇺🇸Reading, Pennsylvania, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Mercy Hospital Cancer Center - Scranton
🇺🇸Scranton, Pennsylvania, United States
Julie and Ben Rogers Cancer Institute
🇺🇸Beaumont, Texas, United States
Bayshore Medical Center
🇺🇸Pasadena, Texas, United States
University of Texas - MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
East Texas Medical Center - Cancer Institute
🇺🇸Tyler, Texas, United States
Gundersen Lutheran Medical Foundation
🇺🇸La Crosse, Wisconsin, United States
St. Vincent Hospital
🇺🇸Green Bay, Wisconsin, United States
Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Schiffler Cancer Center
🇺🇸Wheeling, West Virginia, United States
Deaconess Medical Center
🇺🇸Spokane, Washington, United States
Marshfield Clinic
🇺🇸Marshfield, Wisconsin, United States
University of Wisconsin Comprehensive Cancer Center
🇺🇸Madison, Wisconsin, United States
Community Memorial Hospital
🇺🇸Menomonee Falls, Wisconsin, United States
Southeastern Wisconsin Regional Cancer Center
🇺🇸Racine, Wisconsin, United States
Waukesha Memorial Hospital
🇺🇸Waukesha, Wisconsin, United States
Nova Scotia Cancer Centre
🇨🇦Halifax, Nova Scotia, Canada
Centre Hospitalier Universitaire de Quebec
🇨🇦Quebec City, Quebec, Canada
Ottawa Regional Cancer Centre - General Campus
🇨🇦Ottawa, Ontario, Canada
Cancer Care Ontario-Hamilton Regional Cancer Centre
🇨🇦Hamilton, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal
🇨🇦Montreal, Quebec, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
🇨🇦Thunder Bay, Ontario, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Toronto Sunnybrook Regional Cancer Centre
🇨🇦Toronto, Ontario, Canada
McGill University
🇨🇦Montreal, Quebec, Canada
Vanderbilt-Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
University of Utah Health Sciences Center
🇺🇸Salt Lake City, Utah, United States
Oklahoma University Medical Center
🇺🇸Oklahoma City, Oklahoma, United States
Foundation for Cancer Research and Education
🇺🇸Phoenix, Arizona, United States
CCOP - Columbia River Program
🇺🇸Portland, Oregon, United States
University of Alabama at Birmingham Comprehensive Cancer Center
🇺🇸Birmingham, Alabama, United States
University of Colorado Cancer Center
🇺🇸Denver, Colorado, United States
Mayo Clinic Cancer Center
🇺🇸Rochester, Minnesota, United States
St. Joseph's Hospital
🇺🇸Milwaukee, Wisconsin, United States
St. Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Columbia Hospital
🇺🇸Milwaukee, Wisconsin, United States
Nebraska Health System
🇺🇸Omaha, Nebraska, United States
Methodist Cancer Center - Omaha
🇺🇸Omaha, Nebraska, United States
University of Rochester Cancer Center
🇺🇸Rochester, New York, United States
Memorial Sloan-Kettering Cancer Center
🇺🇸New York, New York, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
🇺🇸Syracuse, New York, United States
CCOP - Santa Rosa Memorial Hospital
🇺🇸Santa Rosa, California, United States
CCOP - Columbus
🇺🇸Columbus, Ohio, United States
Arthur G. James Cancer Hospital - Ohio State University
🇺🇸Columbus, Ohio, United States
CCOP - Upstate Carolina
🇺🇸Spartanburg, South Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Alabama Oncology, LLC
🇺🇸Montgomery, Alabama, United States
California Cancer Center
🇺🇸Fresno, California, United States
Saint Agnes Cancer Center
🇺🇸Fresno, California, United States
Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
Providence Alaska Medical Center
🇺🇸Anchorage, Alaska, United States
MBCCOP - Gulf Coast
🇺🇸Mobile, Alabama, United States
UCSF Cancer Center and Cancer Research Institute
🇺🇸San Francisco, California, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Sutter Health West Cancer Research Group
🇺🇸Greenbrae, California, United States
Cancer Center and Beckman Research Institute, City of Hope
🇺🇸Duarte, California, United States
CCOP - Bay Area Tumor Institute
🇺🇸Oakland, California, United States
Halifax Medical Center
🇺🇸Daytona Beach, Florida, United States
Mount Diablo Medical Center
🇺🇸Concord, California, United States
David Grant Medical Center
🇺🇸Travis Air Force Base, California, United States
Cancer Care Center
🇺🇸Pomona, California, United States
Radiation Medical Group, Inc.
🇺🇸San Diego, California, United States
O'Connor Hospital
🇺🇸San Jose, California, United States
CCOP - Kansas City
🇺🇸Kansas City, Missouri, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
🇺🇸Baltimore, Maryland, United States
Cooper Cancer Institute
🇺🇸Camden, New Jersey, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
CCOP - Kalamazoo
🇺🇸Kalamazoo, Michigan, United States
CCOP - Atlanta Regional
🇺🇸Atlanta, Georgia, United States
St. John's Medical Center
🇺🇸Anderson, Indiana, United States
Vassar Brothers Hospital
🇺🇸Poughkeepsie, New York, United States
Lineberger Comprehensive Cancer Center, UNC
🇺🇸Chapel Hill, North Carolina, United States
MidMichigan Medical Center - Midland
🇺🇸Midland, Michigan, United States
CCOP - Montana Cancer Consortium
🇺🇸Billings, Montana, United States
Cape Cod Hospital
🇺🇸Hyannis, Massachusetts, United States
Veterans Affairs Medical Center - East Orange
🇺🇸East Orange, New Jersey, United States
New York Methodist Hospital
🇺🇸Brooklyn, New York, United States
Albert Einstein Comprehensive Cancer Center
🇺🇸Bronx, New York, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Elliot Regional Cancer Center
🇺🇸Manchester, New Hampshire, United States
Ellis Fischel Cancer Center - Columbia
🇺🇸Columbia, Missouri, United States
South Jersey Regional Cancer Center
🇺🇸Millville, New Jersey, United States
Peninsula Regional Medical Center
🇺🇸Salisbury, Maryland, United States
Mallinckrodt Institute of Radiology
🇺🇸Saint Louis, Missouri, United States
Cancer Center of Albany Medical Center
🇺🇸Albany, New York, United States
McLaren Regional Cancer Center
🇺🇸Flint, Michigan, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Radiation Oncology Affiliates of Maryland, P.A.
🇺🇸Baltimore, Maryland, United States
Veterans Affairs Medical Center - Boston (Jamaica Plain)
🇺🇸Jamaica Plain, Massachusetts, United States
CCOP - Metro-Minnesota
🇺🇸Saint Louis Park, Minnesota, United States
Saint Joseph Medical Center
🇺🇸Albuquerque, New Mexico, United States
East Carolina University School of Medicine
🇺🇸Greenville, North Carolina, United States
Norris Cotton Cancer Center
🇺🇸Lebanon, New Hampshire, United States
CCOP - North Shore University Hospital
🇺🇸Manhasset, New York, United States
Trinitas Hospital - Jersey Street Campus
🇺🇸Elizabeth, New Jersey, United States
Champlain Valley Physicians Hospital Medical Center
🇺🇸Plattsburgh, New York, United States
Finger Lakes Radiation Oncology, P.C.
🇺🇸Clifton Springs, New York, United States
Cancer Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
Beth Israel Medical Center
🇺🇸New York, New York, United States
John F. Kennedy Medical Center
🇺🇸Edison, New Jersey, United States
Riverhill Radiation Oncology
🇺🇸Yonkers, New York, United States
Northeast Medical Center
🇺🇸Concord, North Carolina, United States
Veterans Affairs Medical Center - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
CCOP - Greenville
🇺🇸Greenville, South Carolina, United States
Meritcare Roger Maris Cancer Center
🇺🇸Fargo, North Dakota, United States
Rapid City Regional Hospital
🇺🇸Rapid City, South Dakota, United States
Jackson-Madison County General Hospital
🇺🇸Jackson, Tennessee, United States
Trinity Cancer Care Center
🇺🇸Minot, North Dakota, United States
Akron City Hospital
🇺🇸Akron, Ohio, United States
Barrett Cancer Center, The University Hospital
🇺🇸Cincinnati, Ohio, United States
St. Anthony Hospital
🇺🇸Oklahoma City, Oklahoma, United States
Lehigh Valley Hospital
🇺🇸Allentown, Pennsylvania, United States
Penn State Geisinger Cancer Center
🇺🇸Hershey, Pennsylvania, United States
St. Luke's Hospital Regional Cancer Center
🇺🇸Bethlehem, Pennsylvania, United States
Naval Medical Center, Portsmouth
🇺🇸Portsmouth, Virginia, United States
Harrington Cancer Center
🇺🇸Amarillo, Texas, United States
Dixie Regional Medical Center
🇺🇸Saint George, Utah, United States
Roger Williams Medical Center/BUSM
🇺🇸Providence, Rhode Island, United States
CCOP - MainLine Health
🇺🇸Wynnewood, Pennsylvania, United States
University of Texas Medical Branch
🇺🇸Galveston, Texas, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
LDS Hospital
🇺🇸Salt Lake City, Utah, United States
Cancer Center at the University of Virginia
🇺🇸Charlottesville, Virginia, United States
Joe Arrington Cancer Research and Treatment Center
🇺🇸Lubbock, Texas, United States
Bon-Secours - St. Mary's Hospital
🇺🇸Richmond, Virginia, United States
Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Southern Wisconsin Radiotherapy Center
🇺🇸Madison, Wisconsin, United States
Yakima Valley Memorial Hospital
🇺🇸Yakima, Washington, United States
CCOP - Southwestern Vermont Regional Cancer Center
🇺🇸Bennington, Vermont, United States
Veterans Affairs Medical Center - Milwaukee (Zablocki)
🇺🇸Milwaukee, Wisconsin, United States
Tom Baker Cancer Center - Calgary
🇨🇦Calgary, Alberta, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
Kingston Regional Cancer Centre
🇨🇦Kingston, Ontario, Canada
Newfoundland Cancer Treatment and Research Foundation
🇨🇦St. Johns, Newfoundland and Labrador, Canada
British Columbia Cancer Agency
🇨🇦Vancouver, British Columbia, Canada
CHUS-Hopital Fleurimont
🇨🇦Fleurimont, Quebec, Canada
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
Valley Hospital
🇺🇸Ridgewood, New Jersey, United States
Atlantic City Medical Center
🇺🇸Pomona, New Jersey, United States
St. Francis Medical Center
🇺🇸Trenton, New Jersey, United States
Associated Radiologists, P.A.
🇺🇸Warren, New Jersey, United States
Tallahassee Memorial Healthcare
🇺🇸Tallahassee, Florida, United States
William Beaumont Hospital
🇺🇸Royal Oak, Michigan, United States
William Beaumont Hospital - Troy
🇺🇸Troy, Michigan, United States
Pocono Cancer Center
🇺🇸East Stroudsburg, Pennsylvania, United States
University of Pennsylvania Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Albert Einstein Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Mercy Hospital of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Grand View Hospital
🇺🇸Sellersville, Pennsylvania, United States
Wilkes Barre General Hospital
🇺🇸Wilkes-Barre, Pennsylvania, United States
York Hospital
🇺🇸York, Pennsylvania, United States
Martha Jefferson Hospital
🇺🇸Charlottesville, Virginia, United States
Vermont Cancer Center
🇺🇸Burlington, Vermont, United States
Green Mountain Oncology Group
🇺🇸Rutland, Vermont, United States
Cancer Care Ontario-London Regional Cancer Centre
🇨🇦London, Ontario, Canada
Ball Memorial Hospital
🇺🇸Muncie, Indiana, United States
CCOP - Northern Indiana CR Consortium
🇺🇸South Bend, Indiana, United States
Community Hospitals of Indianapolis - Regional Cancer Center
🇺🇸Indianapolis, Indiana, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
Radiation Oncology Associates of West Alabama
🇺🇸Tuscallosa, Alabama, United States
St. Mary's Medical Center
🇺🇸Saginaw, Michigan, United States
Akron General Medical Center
🇺🇸Akron, Ohio, United States
Monmouth Medical Center
🇺🇸Long Branch, New Jersey, United States
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
🇺🇸Mount Holly, New Jersey, United States
Community Medical Center
🇺🇸Toms River, New Jersey, United States
State University of New York Health Science Center at Brooklyn
🇺🇸Brooklyn, New York, United States
Wilford Hall - 59th Medical Wing
🇺🇸Lackland Air Force Base, Texas, United States
Somerset Medical Center
🇺🇸Somerville, New Jersey, United States
Princess Margaret Hospital
🇨🇦Toronto, Ontario, Canada
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Northeastern Ontario Regional Cancer Centre, Sudbury
🇨🇦Sudbury, Ontario, Canada
Radiation Oncology Center - Sacramento
🇺🇸Sacramento, California, United States
CCOP - Ann Arbor Regional
🇺🇸Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center
🇺🇸Ann Arbor, Michigan, United States
CCOP - Southeast Cancer Control Consortium
🇺🇸Winston-Salem, North Carolina, United States
Comprehensive Cancer Center at Wake Forest University
🇺🇸Winston-Salem, North Carolina, United States
MD Anderson Cancer Center Orlando
🇺🇸Orlando, Florida, United States
Louisville Radiation Oncology
🇺🇸Louisville, Kentucky, United States
James Graham Brown Cancer Center
🇺🇸Louisville, Kentucky, United States
University of Tennessee, Memphis Cancer Center
🇺🇸Memphis, Tennessee, United States
Marquette General Hospital
🇺🇸Marquette, Michigan, United States
Provena St. Joseph Hospital- Regional Cancer Care Center
🇺🇸Elgin, Illinois, United States