To compare the pain relief in patients after operation ,with different doses of Dexmedetomidine (a drug )as added drug to Bupivacaine given in spinal anaesthesia & Bupivacaine alone in Open Uterine surgeries
Phase 1
- Conditions
- Health Condition 1: N852- Hypertrophy of uterusHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2023/09/057299
- Lead Sponsor
- Jubilee Mission Medical College and Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA I & ASA II
PATIENTS SCHEDULED TOTAL ABDOMINAL HYSTERECTOMY
Exclusion Criteria
Patients with baseline Heart rate < 60 or on Beta blockers / Alpha agonist.
Patient refusal for study participation .
Local infection at injection site.
Presence of any coagulopathies or bleeding disorders or patients on anticoagulation.
PRESENCE OF NEUROLOGICAL DEFICITS, PERIPHERAL NEUROPATHIES, MYOPATHIES, OR CHRONIC PAIN IN THE OPERATING LIMB.
PATIENTS WITH KNOWN ALLERGY TO LOCAL ANAESTHETICS OR TO ANY STUDY DRUGS TO BE USED.
HEMODYNAMICALLY COMPROMISED PATIENTS
ALCOHOLIC/ PSYCHIATRIC/UNCOOPERATIVE PATIENTS
PATIENTS WITH HEPATIC / RENAL OR CARDIOPULMONARY DISORDERS.
PATIENTS LESS THAN 5 FEET HEIGHT.
TOTAL ABDOMINAL HYSTERECTOMY TAKING > 3 HRS.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dexmedetomidine 10 mcg was a better adjuvant compared to 5 mcg in terms of better post operative analgesia when used as intrathecal adjuvant to Bupivacaine in subarachnoid blockTimepoint: Post operative analgesia assessed every 6 hours after the requirement of first dose of analgesic
- Secondary Outcome Measures
Name Time Method Onset of sensory block <br/ ><br>Onset of motor block <br/ ><br>Level of block achieved Duration of sensory block <br/ ><br>Duration of motor blockTimepoint: After administration of subarachnoid block <br/ ><br>Onset of block ever 2 minutes <br/ ><br>Duration of block every 6 hours <br/ ><br>