A randomised, cluster controlled trial to investigate the effects of a programme of intradialytic exercise on cardiovascular outcomes in haemodialysis patients.

niversity of Leicester (UK)0 sites130 target enrollmentMarch 5, 2015

Overview

2016 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/27391774 protocol 2021 Results article in https://doi.org/10.1016/j.kint.2021.02.027 Effects on left ventricular mass (added 04/05/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34854982/ Effect of cycling on microparticles or circulating markers of systemic inflammation (added 03/12/2021) 2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/33148767/ Feasibility substudy in frail patients (added 25/07/2022) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/34169195/ Cost-effective analysis (added 08/04/2024) 2018 Other publications in https://pubmed.ncbi.nlm.nih.gov/30005636/ Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance (added 08/04/2024) 2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/33258084/ The cardiovascular determinants of physical function in patients with end-stage kidney disease on haemodialysis (added 08/04/2024) 2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/32507107/ The reliability and feasibility of non-contrast adenosine stress cardiovascular magnetic resonance T1 mapping in patients on haemodialysis (added 08/04/2024) 2024 Other publications in https://pubmed.ncbi.nlm.nih.gov/39050864/ Impact of physical activity on surrogate markers of cardiovascular disease (added 29/07/2024)

Registry

who.int

Start Date

March 5, 2015

End Date

January 31, 2019

Last Updated

last year

Study Type

Interventional

Sex

All

Sponsor

niversity of Leicester (UK)

•1\. Be a prevalent haemodialysis patient (on haemodialysis for more than 3 months)
•2\. Age 18 years or older
•3\. Able and willing to give informed consent

•1\. Unable to participate in current exercise program due to perceived physical or psychological barriers
•2\. Unable to undergo MRI scanning (metal implants / prostheses, claustrophobia etc.)
•3\. Unfit to undertake exercise according to the American College of Sports Medicine guidelines
•4\. Contraindications to exercise testing (35\) that include:
•4\.1\. Recent significant change in resting ECG that suggests significant ischaemia, recent myocardial infarction (2 weeks) or other acute cardiac event;
•4\.2\. Unstable angina;
•4\.3\. Uncontrolled cardiac dysrhythmias causing symptoms or haemodynamic compromise;
•4\.4\. Symptomatic severe aortic stenosis
•4\.5\. Uncontrolled symptomatic heart failure
•4\.6\. Acute pulmonary embolus or pulmonary infarction