Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- oocyte survival rate 1 day after ICSI
Study Overview
Brief Summary
Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Factorial
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosis of infertility
- •Scheduled for IVF with ICSI
Exclusion Criteria
- •Retrieval of fewer than 6 mature oocytes
Outcomes
Primary Outcomes
oocyte survival rate 1 day after ICSI
Secondary Outcomes
- embryo fragmentation rates 2 and 3 days after ICSI
- embryo compaction rate through day 7 after ICSI
- normal fertilization rate 1 day after ICSI
- embryo cell numbers 2 and 3 days after ICSI
- blastocyst formation rate through day 7 after ICSI