NL-OMON51867已完成不适用
The intracellular pharmacokinetics of tacrolimus in CD3+ T lymphocytes - INTACT
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age * 18 years.
- •- Recipient of a kidney transplant at the Erasmus MC.
- •- Use once-daily tacrolimus as part of routine maintenance immunosuppression
- •starting the day of surgery.
- •- Written informed consent.
排除标准
- •Patients who receive lymphocyte depleting agents (thymoglobuline,
- •anti-thymocyte globulin, and alemtuzumab) as an induction therapy or
- •anti-rejection treatment before enrolment. Recipients using medication known to
- •have a pharmacokinetic (drug-drug) interaction with tacrolimus: Antibiotics
- •(Clarithromycin, Doxycyclin, Erythromycin, Rifampicin), Antiepileptics
- •(Carbamazepine, Phenobarbital, Phenytoin), Antihypertensive and antiarrhythmic
- •agents (Amiodarone, Diltiazem, Verapamil), Antimycotic drugs (Fluconazole,
- •Itraconazole, Ketoconazole), Other (HIV protease inhibitors, Theophyllin)
研究者
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