The effect of music therapy on the stress-level of small preterm infants
- Conditions
- Small preterm infantsR45.7State of emotional shock and stress, unspecified
- Registration Number
- DRKS00005787
- Lead Sponsor
- eonatologie der Kinderklinik am Perinatalznetrum der LMU-München, Grosshadern
- Brief Summary
Salivary cortisol was significantly lower 25 min (18.9 nmol/L [3.9–35.6] p = 0.001) and 4 h after music (17.4 nmol/L [3.9–35.3] p = 0.003) than at baseline 4 h before exposure (19.5 nmol/L [7.2–51.1]). After music, the number of apnoeas and oxygen desaturations was significantly reduced on all three, days and the number of bradycardia episodes on day one. Pain scores significantly improved after music on all 3 days.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
(1) preterm infants born at 500 -1499g birthweight; (2) On full enteral nutrition; (3) not on any analgesic or sedating drug; (4) within 48 hours prior to music exposition: no signs of infection (increased CrP), no surfactant treatment, no arterial hypotension, no need for systemic or inhaled steroids, no IVH of any grade, no blood glucose < 40 mg/dl, no blood transfusion, not on any respiratory support
(5) Written parental consent.
(1) Small for gestational age below 3. percentile; (2) severe malformations; chromosomal aberrations, vitium cordis, (except patent ductus arteriosus or atrial septal defect (3) family history or manifest adrenal malfunction (e.g. Adreno-genital.syndrome); (4) IVH>/=°I; (5) negative hearing screen in any ear.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome of the study is the salivary cortisol level, measured from saliva collected prior to live harp music by mass spectrometry, 25 minutes and 4 hours after pentatonic live harp exposition.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are the number of bradycardia below 100/min; the frequency of desaturations below 85% (mean values 4 hrs prior and 4 hrs after music) and the measured value of the bernese pain score for newborns prior to music, immediately after music, 40 min and 4 hours after Music