The Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular Hypertrophy

University of Aarhus1 site in 1 country11 target enrollmentFebruary 2011

ConditionsLeft Ventricular Hypertrophy Diastolic Dysfunction Heart Failure Heart Rate

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Left Ventricular Hypertrophy
Sponsor: University of Aarhus
Enrollment: 11
Locations: 1
Primary Endpoint: Cardiac index
Status: Terminated
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to compare the effect of heart rate on cardiac index in patients with or without left ventricular hypertrophy. The study will be conducted in postoperative heart surgery patients with a pacemaker.

Registry

clinicaltrials.gov

Start Date

February 2011

End Date

August 2012

Last Updated

13 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Aarhus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Scheduled heart surgery including thoracotomy
•Ejection fraction \> 45%
•Duration of QRS complex \< 120 milliseconds
•Sinus rhythm
•Planned perioperative temporary pacemaker
•Group: Left ventricular hypertrophy:
•Thickness of interventricular septum and posterior wall \>11 mm.
•Group: No left ventricular hypertrophy:
•Thickness of interventricular septum and posterior wall \<11 mm.

Exclusion Criteria

•Active endocarditis
•Severe mitral insufficiency
•No patient consent

Outcomes

Primary Outcomes

Cardiac index

Time Frame: At heart rates 65-80-95-110-125

Secondary Outcomes

Mean arterial blood pressure(At heart rates 65-80-95-110-125)
Ejection fraction(Heart rates of 65-80-95-110-120)
Strain(Heart rates of 65-80-95-110-125)
S-max(Heart rates of 65-80-95-110-125 beats per second)
E/E'(Heart rates of 65-80-95-110-125 beats per second)
E/A ratio(Heart rates of 65-80-95-110-125 beats per second)
E'/A' ratio(Heart rates of 65-80-95-110-125 beats per second)
Isovolumetric relaxation index(Heart rates of 65-80-95-110-125 beats per second)
IVRT/IVRT'(Heart rates of 65-80-95-110-125 beats per second)
End diastolic volume(Heart rates of 65-80-95-110-125 beats per second)
End systolic volume(Heart rates of 65-80-95-110-125 beats per second)