Double Carbapenem as Rescue Strategy for the Treatment of Carbapenemase-Producing Klebsiella Pneumoniae Infections

Completed

• Conditions: Carbapenem; Klebsiella Pneumonia
• Interventions: Other: none intervention

• Registration Number: NCT03094494
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

An observational two-center case-control study exploring the clinical impact of double-carbapenem use in a population of critically il patients with severe carbapenem-resistant Klebsiella pneumoniae infection

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11-01
• Primary Completion: 2015-12-31
• Study Completion: 2016-12-31
• Status Verified: 2017-03
• Study First Submitted: 2017-03-23
• Study First Submitted QC: 2017-03-28
• Last Update Submitted: 2017-03-28
• Study First Posted: 2017-03-29
• Last Update Posted: 2017-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

1. age ≥ 18 years;
2. ICU admission between November 2012 and December 2015;
3. documented CR-Kp invasive infection;
4. targeted antibiotic therapy lasting ≥ 72 hours

Exclusion Criteria

1. Klebsiella infection, susceptible to carbapenems
2. Duration of antimicrobial therapy less than 72 hours
3. Data not completely available from the electronically medical chart

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Double Carbapenem Group	none intervention	Patients underwent Double carbapenem treatment
Standard Treatment Group	none intervention	Patients who were not treated with the double carbapenem

Primary Outcome Measures

Name	Time	Method
28-day mortality	28 day	mortality after 28 day from infection